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. 1993 Feb;50(2):155–159. doi: 10.1136/oem.50.2.155

Systemic effects of inhalational methyl bromide poisoning: a study of nine cases occupationally exposed due to inadvertent spread during fumigation.

W N Hustinx 1, R T van de Laar 1, A C van Huffelen 1, J C Verwey 1, J Meulenbelt 1, T J Savelkoul 1
PMCID: PMC1061253  PMID: 8435348

Abstract

Systemic methyl bromide (CH3Br) poisoning with signs and symptoms of varying severity developed in nine greenhouse workers after acute inhalational exposure on two consecutive days. Measurements of CH3Br, carried out at the site within hours after the accident, suggest that exposure on the second day may have been in excess of 200 ppm (800 mg/m3) CH3Br. All workers were admitted for observation. Seven of them were discharged after an uneventful overnight observation and residual symptoms, if any, subsided within three weeks of the accident. Two patients needed intensive care for several weeks because of severe reactive myoclonus and tonic-clonic generalised convulsions. These conditions were unresponsive to repeated doses of diazepam, clonazepam, and diphenylhydantoin but could be suppressed effectively by induction of a thiopental coma that had to be continued for three weeks. In some of the patients prior subchronic exposure to CH3Br, as shown by their occupational histories and high serum bromide (Br-) concentrations, is likely to have been a factor contributing to the severity of their symptoms. A direct association between serum Br- concentrations and the severity of neurological symptoms, however, seemed to be absent. An on site investigation into the circumstances leading to the accident showed the presence of an empty and out of use drainage system that covered both sections of the greenhouse. This was probably the most important factor contributing to the rapid and inadvertent spread of CH3Br.

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Selected References

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  1. Alexeeff G. V., Kilgore W. W. Methyl bromide. Residue Rev. 1983;88:101–153. doi: 10.1007/978-1-4612-5569-7_3. [DOI] [PubMed] [Google Scholar]
  2. Behrens R. H., Dukes D. C. Fatal methyl bromide poisoning. Br J Ind Med. 1986 Aug;43(8):561–562. doi: 10.1136/oem.43.8.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Herzstein J., Cullen M. R. Methyl bromide intoxication in four field-workers during removal of soil fumigation sheets. Am J Ind Med. 1990;17(3):321–326. doi: 10.1002/ajim.4700170304. [DOI] [PubMed] [Google Scholar]
  4. Hine C. H. Methyl bromide poisoning. A review of ten cases. J Occup Med. 1969 Jan;11(1):1–10. [PubMed] [Google Scholar]
  5. Honma T., Miyagawa M., Sato M., Hasegawa H. Neurotoxicity and metabolism of methyl bromide in rats. Toxicol Appl Pharmacol. 1985 Nov;81(2):183–191. doi: 10.1016/0041-008x(85)90154-1. [DOI] [PubMed] [Google Scholar]
  6. Marraccini J. V., Thomas G. E., Ongley J. P., Pfaffenberger C. D., Davis J. H., Bednarczyk L. R. Death and injury caused by methyl bromide, an insecticide fumigant. J Forensic Sci. 1983 Jul;28(3):601–607. [PubMed] [Google Scholar]
  7. Mellerio F., Levy-Alcover M. A. Myoclonies d'origine toxique. Rev Electroencephalogr Neurophysiol Clin. 1982 Nov;12(3):210–218. doi: 10.1016/s0370-4475(82)80046-4. [DOI] [PubMed] [Google Scholar]
  8. RATHUS E. M., LANDY P. J. Methyl bromide poisoning. Br J Ind Med. 1961 Jan;18:53–57. doi: 10.1136/oem.18.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. SOREMARK R. Distribution and kinetics of bromide ions in the mallalian body: some experimental investigations using Br80m and Br82. Acta Radiol Suppl. 1960;190:1–114. [PubMed] [Google Scholar]
  10. Sangster B., Blom J. L., Sekhuis V. M., Loeber J. G., Rauws A. G., Koedam J. C., Krajnc E. I., van Logten M. J. The influence of sodium bromide in man: a study in human volunteers with special emphasis on the endocrine and the central nervous system. Food Chem Toxicol. 1983 Aug;21(4):409–419. doi: 10.1016/0278-6915(83)90095-9. [DOI] [PubMed] [Google Scholar]
  11. Shield L. K., Coleman T. L., Markesbery W. R. Methyl bromide intoxication: neurologic features, including simulation of Reye syndrome. Neurology. 1977 Oct;27(10):959–962. doi: 10.1212/wnl.27.10.959. [DOI] [PubMed] [Google Scholar]
  12. Uncini A., Basciani M., Di Muzio A., Antonini D., Onofrj M. Methyl bromide myoclonus: an electrophysiological study. Acta Neurol Scand. 1990 Feb;81(2):159–164. doi: 10.1111/j.1600-0404.1990.tb00953.x. [DOI] [PubMed] [Google Scholar]
  13. Van Den Oever R. U., Roosels D., Lahaye D. Actual hazard of methyl bromide fumigation in soil disinfection. Br J Ind Med. 1982 May;39(2):140–144. doi: 10.1136/oem.39.2.140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Zwaveling J. H., de Kort W. L., Meulenbelt J., Hezemans-Boer M., van Vloten W. A., Sangster B. Exposure of the skin to methyl bromide: a study of six cases occupationally exposed to high concentrations during fumigation. Hum Toxicol. 1987 Nov;6(6):491–495. doi: 10.1177/096032718700600607. [DOI] [PubMed] [Google Scholar]
  15. van Leeuwen F. X., Sangster B. The toxicology of bromide ion. Crit Rev Toxicol. 1987;18(3):189–213. doi: 10.3109/10408448709089861. [DOI] [PubMed] [Google Scholar]

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