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. 1993 Apr;50(4):317–324. doi: 10.1136/oem.50.4.317

Cancer mortality in ethylene oxide workers.

L Bisanti 1, M Maggini 1, R Raschetti 1, S S Alegiani 1, F M Ippolito 1, B Caffari 1, N Segnan 1, A Ponti 1
PMCID: PMC1061288  PMID: 8494771

Abstract

A cohort of 1971 chemical workers licensed to handle ethylene oxide was followed up retrospectively from 1940 to 1984 and the vital status of each subject was ascertained. No quantitative information on exposure was available and therefore cohort members were considered as presumably exposed to ethylene oxide. The cohort comprised 637 subjects allowed to handle only ethylene oxide and 1334 subjects who obtained a licence valid for ethylene oxide as well as other toxic gases. Potential confounding arising from the exposure to these other chemical agents was taken into consideration. Causes of death were found from death certificates and comparisons of mortality were made with the general population of the region where cohort members were resident. Seventy six deaths were reported whereas 98.8 were expected; the difference was statistically significant. The number of malignancies for any site exceeded the expected number (standardised mortality ratio (SMR) = 130; 43 observed deaths; 95% confidence interval (95% CI) 94-175) and approached statistical significance. For all considered cancer sites the SMRs were higher than 100 but the excess was only significant (p < 0.05, two sided test) for lymphosarcoma and reticulosarcoma (International Classification of Diseases--9th revision (ICD-9) = 200; SMR = 682; four observed deaths; 95% CI 186-1745). The excess of cases for all cancers of haematopoietic tissue (ICD-9 = 200-208) also approached statistical significance (SMR = 250; six observed deaths; 95% CI 91-544). Focusing the analysis on the subcohort of the ethylene oxide only licensed workers, who are likely to have experienced a more severe exposure to this gas, it became evident that all but one of the observed cases of haematopoietic tissue cancers in the cohort were confined to this subgroup, enhancing the relevant SMR to 700 (95% CI 237-1637) and the SMR of lymphosarcoma and reticulosarcoma to 1693 (95% CI 349-4953).

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Selected References

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  1. Albert D. M., Puliafito C. A. Choroidal melanoma: possible exposure to industrial toxins. N Engl J Med. 1977 Mar 17;296(11):634–635. doi: 10.1056/nejm197703172961119. [DOI] [PubMed] [Google Scholar]
  2. Axelson O., Steenland K. Indirect methods of assessing the effects of tobacco use in occupational studies. Am J Ind Med. 1988;13(1):105–118. doi: 10.1002/ajim.4700130107. [DOI] [PubMed] [Google Scholar]
  3. Bettendorf U. Berufsbedingte Lungenkarzinome nach Inhalation alkylierender Verbindungen. Dichlordimethyläther, Monochlordimethyläther und Dimethylsulfat. Dtsch Med Wochenschr. 1977 Mar 18;102(11):396–398. doi: 10.1055/s-0028-1104899. [DOI] [PubMed] [Google Scholar]
  4. Divine B. J., Amanollahi K. S. Ethylene oxide and cancer. JAMA. 1986 Oct 3;256(13):1726–1727. doi: 10.1001/jama.1986.03380130054023. [DOI] [PubMed] [Google Scholar]
  5. Galloway S. M., Berry P. K., Nichols W. W., Wolman S. R., Soper K. A., Stolley P. D., Archer P. Chromosome aberrations in individuals occupationally exposed to ethylene oxide, and in a large control population. Mutat Res. 1986 Apr-May;170(1-2):55–74. doi: 10.1016/0165-1218(86)90082-0. [DOI] [PubMed] [Google Scholar]
  6. Gardner M. J., Coggon D., Pannett B., Harris E. C. Workers exposed to ethylene oxide: a follow up study. Br J Ind Med. 1989 Dec;46(12):860–865. doi: 10.1136/oem.46.12.860. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Greenberg H. L., Ott M. G., Shore R. E. Men assigned to ethylene oxide production or other ethylene oxide related chemical manufacturing: a mortality study. Br J Ind Med. 1990 Apr;47(4):221–230. doi: 10.1136/oem.47.4.221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hertz-Picciotto I., Neutra R. R., Collins J. F. Ethylene oxide and leukemia. JAMA. 1987 May 1;257(17):2290–2290. doi: 10.1001/jama.257.17.2290b. [DOI] [PubMed] [Google Scholar]
  9. Hogstedt C., Aringer L., Gustavsson A. Epidemiologic support for ethylene oxide as a cancer-causing agent. JAMA. 1986 Mar 28;255(12):1575–1578. [PubMed] [Google Scholar]
  10. Hogstedt C., Malmqvist N., Wadman B. Leukemia in workers exposed to ethylene oxide. JAMA. 1979 Mar 16;241(11):1132–1133. [PubMed] [Google Scholar]
  11. Hogstedt C., Rohlén O., Berndtsson B. S., Axelson O., Ehrenberg L. A cohort study of mortality and cancer incidence in ethylene oxide production workers. Br J Ind Med. 1979 Nov;36(4):276–280. doi: 10.1136/oem.36.4.276. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kiesselbach N., Ulm K., Lange H. J., Korallus U. A multicentre mortality study of workers exposed to ethylene oxide. Br J Ind Med. 1990 Mar;47(3):182–188. doi: 10.1136/oem.47.3.182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kohn H. I., Fry R. J. Radiation carcinogenesis. N Engl J Med. 1984 Feb 23;310(8):504–511. doi: 10.1056/NEJM198402233100807. [DOI] [PubMed] [Google Scholar]
  14. Morgan R. W., Claxton K. W., Divine B. J., Kaplan S. D., Harris V. B. Mortality among ethylene oxide workers. J Occup Med. 1981 Nov;23(11):767–770. doi: 10.1097/00043764-198111000-00011. [DOI] [PubMed] [Google Scholar]
  15. Snellings W. M., Weil C. S., Maronpot R. R. A two-year inhalation study of the carcinogenic potential of ethylene oxide in Fischer 344 rats. Toxicol Appl Pharmacol. 1984 Aug;75(1):105–117. doi: 10.1016/0041-008x(84)90081-4. [DOI] [PubMed] [Google Scholar]
  16. Steenland K., Stayner L., Greife A., Halperin W., Hayes R., Hornung R., Nowlin S. Mortality among workers exposed to ethylene oxide. N Engl J Med. 1991 May 16;324(20):1402–1407. doi: 10.1056/NEJM199105163242004. [DOI] [PubMed] [Google Scholar]

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