Author response table 1.

MFN2 mutant	GTPase activity	Conformation change	Fusion	Polarization	Respiration	Mitophagy	Motility	KI phenotype
T105M	Inactive	Normal	Dominant suppressor	Dominant suppressor	Dominant suppressor	Normal	Dominant suppressor	CMT2A (het) Emb let (homo)
M376A/V	Normal	Impaired	Functional null	Normal	Functional null	Normal	Normal	Normal
R400Q	Normal	Impaired	Dominant suppressor	Normal	Functional null	Dominant suppressor	Normal	Cardiomyopathy (homo)