Table 3.

Combination therapy of phage depolymerase and some antibiotics in the treatment of bacterial biofilm.

Depolymerase	Origin phage	Phage family	Bacterium genus	Antibiotics	Combined outcome	Substrate	Application model	Study references
Dep42	SH-KP152226	Podoviridae	K. pneumoniae	polymyxin	synergy	K47 capsule	In vitro	[15]
KPO1K2 associated depolymerase	KPO1K2	-	K. pneumoniae	ciprofloxacin	synergy	biofilm	In vitro	[110]
DepoKP36	vB_KpnS_KP36	Siphoviridae	K. pneumoniae	ciprofloxacin, oxytetracycline, and chloramphenicol	synergy	K63 capsule	Galleria mellonella	[13]
Dpo71	IME-AB2	-	A. baumannii	colistin	synergy	Biofilm	Galleria mellonella	[16]
KP34p57	KP34	-	K. pneumoniae	ciprofloxacin	Neutral	Biofilm	In vitro	[111]
DpoMK34	vB_AbaP_PMK34	-	A. baumannii	Imipenem, amikacin, and colistin	Neutral	K2 capsule	In vitro	[14]
TF	φAB2	-	A. baumannii	colistin	antagonism	exopolysaccharide (EPS)	In vitro	[112]