Figure 4. In vivo treatment of breast cancer using FAAH inhibitors.
Twenty 6-week-old female immune-deficient NU/J mice were aged to 8 weeks before being implanted with 2 million MDA-MB-231 breast cancer cells each. Mice were treated with a vehicle control or the FAAH inhibitor, URB597. Externally visible tumor size was measured over 60 days using calipers and images were also taken at specific timepoints; these are plotted in (A). (B) Three examples of mice from the vehicle group are displayed. (C) Three examples of mice from the drug treatment group are displayed.