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. 2023 Oct 10;309(1):e231092. doi: 10.1148/radiol.231092

Figure 3:

Schematic shows adaptive enrollment for determining the stopping rule for the interim analysis after enrollment of 12 participants, the results of which are used to determine if more participants need to be included in the final analysis. If the a priori upper bound 95% confidence threshold is met for each biomarker, no additional participants would be recruited. If a single biomarker or multiple biomarkers failed to meet the threshold, additional participants would be enrolled with another interim analysis planned upon enrollment of 21 and 24 participants. CSE = chemical shift encoding, MRE = MR elastography, PDFF = proton density fat fraction, RCdiff-day = different-day repeatability coefficient, 3D = three-dimensional, 2D = two-dimensional, VAT = visceral adipose tissue.

Schematic shows adaptive enrollment for determining the stopping rule for the interim analysis after enrollment of 12 participants, the results of which are used to determine if more participants need to be included in the final analysis. If the a priori upper bound 95% confidence threshold is met for each biomarker, no additional participants would be recruited. If a single biomarker or multiple biomarkers failed to meet the threshold, additional participants would be enrolled with another interim analysis planned upon enrollment of 21 and 24 participants. CSE = chemical shift encoding, MRE = MR elastography, PDFF = proton density fat fraction, RCdiff-day = different-day repeatability coefficient, 3D = three-dimensional, 2D = two-dimensional, VAT = visceral adipose tissue.