Abstract
Prolonged juvenile hypothyroidism results in a permanent loss in height that is related to the duration of thyroxine deficiency before adequate thyroxine replacement treatment. A 13 year old girl with severe juvenile hypothyroidism was studied prospectively. She had an undetectable serum thyroxine concentration, a height SD score of -6.6 SD, and a bone age of 5.8 years. The enlarged pituitary gland involuted with thyroxine treatment to produce an empty sella. In addition to thyroxine the girl was treated with a gonadotrophin releasing hormone agonist to avoid the progression of puberty for 18 months and with growth hormone to achieve normal adult height.
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Selected References
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- Hibi I., Tanaka T., Tanae A., Kagawa J., Hashimoto N., Yoshizawa A., Shizume K. The influence of gonadal function and the effect of gonadal suppression treatment on final height in growth hormone (GH)-treated GH-deficient children. J Clin Endocrinol Metab. 1989 Aug;69(2):221–226. doi: 10.1210/jcem-69-2-221. [DOI] [PubMed] [Google Scholar]
- Pantsiouou S., Stanhope R., Uruena M., Preece M. A., Grant D. B. Growth prognosis and growth after menarche in primary hypothyroidism. Arch Dis Child. 1991 Jul;66(7):838–840. doi: 10.1136/adc.66.7.838. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rivkees S. A., Bode H. H., Crawford J. D. Long-term growth in juvenile acquired hypothyroidism: the failure to achieve normal adult stature. N Engl J Med. 1988 Mar 10;318(10):599–602. doi: 10.1056/NEJM198803103181003. [DOI] [PubMed] [Google Scholar]
- Stahnke N., Koehn H. Replacement therapy in hypothalamus-pituitary insufficiency: management in the adolescent. Horm Res. 1990;33 (Suppl 4):38–44. doi: 10.1159/000181582. [DOI] [PubMed] [Google Scholar]
- di Natale B., Scotti G., Pellini C., Del Maschio A., Triulzi F., Petecca C., Uboldi F., Chiumello G. Empty sella in children with pituitary dwarfism: does it exist? Pediatrician. 1987;14(4):246–252. [PubMed] [Google Scholar]