Figure 2–2. Fragmentation and other NMJ metrics measured across the lifespan for male and female ΔIg3-MuSK mice separately.

Morphometric analysis of NMJs in males (a-e) and female (f-j) at the indicated ages. Fragmentation (a, f), nerve terminal area (b, g), AChR area (c, h), endplate area (d, i), overall area of the endplate region, and (e, j) compactness ratio of male ΔIg3-MuSK NMJs throughout the lifespan. (* p<0.05, ** p<0.01, *** p<0.001, generalized linear models, full statistics are presented in Tables 1-1 and 1-2 (male), 1-3 and 1-4 (female), including median and interquartile range for each measurement, n for each age and sex, tests used, and results of statistical testing.)