Table 1–3. Female-only sternomastoid NMJ morphometry data across lifespan.
Data for each timepoint studied presented as: Median value (interquartile range). Sample sizes (animals and synapses) indicated for each timepoint.
| Age | P14 | P21 | ||
|---|---|---|---|---|
| Genotype | WT | ΔIg3-MuSK | WT | ΔIg3-MuSK |
| Nerve Terminal Area (μm 2 ) | 144.876 (111.257, 179.09) | 120.92 (97.153, 152.366) | 168.907 (137.1, 193.341) | 149.531 (128.786, 171.86) |
| AChR Area (μm2) | 178.109 (129.585, 225.513) | 175.97 (135.225, 212.373) | 200.144 (159.504, 243.861) | 203.604 (169.714, 247.225) |
| Endplate Area (μm2) | 250.278 (193.114, 321.843) | 259.161 (201.548, 341.547) | 319 (259.589, 377.833) | 332.123 (263.407, 438.502) |
| Compactness | 0.688 (0.643, 0.74) | 0.676 (0.63, 0.723) | 0.632 (0.588, 0.678) | 0.597 (0.543, 0.665) |
| Fragmentation | 1 (1, 1) | 1 (1, 1) | 2 (1, 3) | 2.5 (2, 4) |
| N NMJs) | 107 | 111 | 109 | 82 |
| N (animals) | 6 F | 6 F | 7 F | 6 F |
| Age | 3 months | 14 months | ||
| Genotype | WT | ΔIg3-MuSK | WT | ΔIg3-MuSK |
| Nerve Terminal Area (μm2) | 245.317 (202.371, 309.119) | 243.71 (201.534, 332.303) | 249.204 (196.868, 301.528) | 274.171 (204.904, 326.748) |
| AChR Area (μm2) | 300.861 (236.484, 383.337) | 332.811 (267.228, 405.978) | 305.688 (250.328, 379.665) | 345.98 (258.727, 419.558) |
| Endplate Area (μm2) | 632.879 (439.32, 770.373) | 722.336 (517.699, 950.281) | 661.905 (511.766, 881.899) | 727.734 (556.111, 1104.843) |
| Compactness | 0.514 (0.474, 0.558) | 0.49 (0.423, 0.535) | 0.464 (0.41, 0.521) | 0.465 (0.396, 0.561) |
| Fragmentation | 4 (2.25, 5) | 5.5 (4, 9) | 5 (3, 6) | 6.5 (4, 8.25) |
| N (NMJs) | 74 | 64 | 103 | 60 |
| N (Animals) | 6 F | 6 F | 8 F | 5 F |