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[Preprint]. 2023 Nov 1:2023.10.27.564474. [Version 1] doi: 10.1101/2023.10.27.564474

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Figure 3. — (A) Volcano plot showing differential gene expression of analysis of Osmr^fl/fl Mx1-Cre vs. control Mx1-Cre HSCs (n = 3–6 biological replicates). Select significantly differentially expressed genes (p < 0.01, log2(FC) > 3 or < −3) are shown in red (down) or blue (up) font. (B) Count per million reads of Osmr transcript in control Mx1-Cre and Osmr^fl/fl Mx1-Cre HSCs. Bars show low to high values with a line at the mean. (C) Gene signature enrichment within differentially expressed genes between Osmr^fl/fl Mx1-Cre and control Mx1-Cre HSCs. (D) Heatmap of 37 genes induced by 60min OSM stimulation in control Mx1-Cre HSCs. Three patterns were observed: Group (I) genes were no longer induced by OSM in Osmr^fl/fl Mx1-Cre HSCs, group (II) genes induced by OSM in both control Mx1-Cre and Osmr^fl/fl Mx1-Cre HSCs, and group (III) genes induced by OSM in control Mx1-Cre HSCs but repressed by OSM in Osmr^fl/fl Mx1-Cre HSCs. (E) Gene signature enrichment within group (I) genes. (F) Gene signature enrichment within group (III) genes.