Skip to main content
[Preprint]. 2024 Jul 5:2023.10.27.23297507. Originally published 2023 Oct 27. [Version 2] doi: 10.1101/2023.10.27.23297507

Figure 1. Study design to identify and understand the genetic determinants of coronary artery dominance.

Figure 1.

(A) Variation in the posterior descending artery (PDA) determines dominance in the human heart. (B) A multi-ancestry genome-wide association study (GWAS) was performed using genotype data from participants in MVP whose coronary arteries were imaged via angiogram. Analyses were conducted in all participants combined and in cohorts stratified by genetically inferred ancestry. Whole-organ immunolabeling of fetal hearts investigated when dominance is established, and mouse studies validated the most significant genetic association. CAs, coronary arteries.