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. Author manuscript; available in PMC: 2024 Aug 31.
Published in final edited form as: Cell. 2023 Aug 18;186(18):3882–3902.e24. doi: 10.1016/j.cell.2023.07.019

Figure 6. TF programs are durably altered following severe COVID-19 and are shared between HSPC and CD14 + monocytes.

Figure 6.

(A) Differentially active TFs in HSPC (left) and CD14+ monocytes (right) between Healthy and Early/Late groups.

(B-C) chromVAR scores for IRF2 in HSPC (B) and CD14+ monocytes (C). Scores projected on myeloid UMAP (left). Per-cell scores across groups (right).

(D) Average expression of representative marker genes of M.SC3 in each individual.

(E-F) M.SC3 module score in myeloid cells (E) and HSPC (F). M.SC3 module score is projected onto UMAP (left). Per-cell M.SC3 module score across groups (right).