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. 2023 Nov 13;11:249. doi: 10.1186/s40168-023-01694-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Fecal extracellular vesicles (EVs) of pregnant women show accumulation to fetus in pregnant mice. Labeled EVs isolated from the feces of pregnant women were injected intravenously into the mice at the end of the first stage of pregnancy. The animals were sacrificed 24 h after injection, and images of various organs and fetuses were obtained. Fluorescent intensity was assessed in various maternal organs and fetuses. The data are shown as means, with standard deviation shown by the error bar, n = 4 mice, nonsignificant (ns) between organs/fetuses in the Kruskal–Wallis nonparametric test (A). Representative fluorescence image of the organs and fetuses indicated, with regions of interest (ROI) of similar size are drawn in (B)