Figure 4. Photoreceptor genes important for phototransduction are downregulated in all homeodomain (HD) mutants.
(A) Box plot showing that genes in the detection of light stimulus gene ontology (GO) term were downregulated and affected to various degrees in different adult (P21) HD mutant mouse retinas. (B) Heatmap showing that expression of both cone and rod phototransduction genes were downregulated in adult (P21) HD mutant mouse retinas. Annotation of rod and cone enrichment of each gene is in Supplementary file 1f. See Figure 4—figure supplement 1 for the developmental expression dynamics of these genes.