TABLE 1.
Contacts of the (3-17)-N-terminal H3 P1 peptide with ankyrin domain (ANK), post-SET, and core-SET a c
| H3 peptide | ANK | Post-SET | Core-SET |
|---|---|---|---|
| Thr3 | Asn232 | Asp197 | |
| Lys | Asp409 Ile447 b Asp451 Asp448 (back) Glu449 (back) |
Tyr236 (stacking) | |
| Gln5 |
Thr445
Tyr446 (stacking) |
||
| Thr6 |
Thr445 (backbone) His489 Asn493 b |
||
| Ala7 |
His489
Phe492 |
||
| Arg8 |
Asn234
Thr235 |
||
| Lys9 (backbone) | Tyr236 | ||
| Ser10 |
Tyr236
Glu237 Glu238 (backbone) |
||
| Thr11 | Thr235 | ||
| Gly12 |
Thr235
Glu237 |
||
| Gly13 | Thr235 |
Lys170 (backbone) Ala173 (backbone) Tyr233 |
|
| Lys14 |
Tyr148
Ser171 (backbone) Ala173 (backbone) Met174 Tyr175 (backbone) Tyr233 SAM |
||
| Ala15 |
Met174
Phe204 Tyr233 (backbone) |
||
| Pro16 (backbone) |
Tyr175 (backbone) Val176 Phe204 Asn234 |
||
| Arg17 (backbone) |
Phe204 (backbone) Asn234 |
||
| Arg17 | Glu206 |
a
Core-SET: 115–234aa; post-SET: 235–253aa; ANK: 256–545aa. Active site: Tyr233, corresponding to Tyr220 in the 532aa form and Tyr249 in the 561aa form.
b
Key residues connected to H3 peptides.
c
Contacts shorter than 3.65 Å are shown in bold; remaining are contacts closer than 4 Å.