Table 1.
Ingenuity pathway analysis of NF-κB-related upstream regulators in BRAF-mutated PTC.
| Upstream regulator | Molecule type | Activation z-score | p value |
|---|---|---|---|
| TNF | cytokine | 7.321 | 4.33E–50 |
| LPS | chemical drug | 6.294 | 5.43E–30 |
| IL6 | cytokine | 3.813 | 6.16E–27 |
| IL1B | cytokine | 4.503 | 2.62E–26 |
| IL1 | group | 4.485 | 6.81E–18 |
| IKBΚB / IKKβ | kinase | 2.079 | 5.54E–17 |
| IL13 | cytokine | 2.308 | 9.62E–17 |
| NFκB (complex) | complex | 4.343 | .398E–15 |
| CHUK / IKKα | kinase | 2.591 | 3.54E–14 |
| PI3K (complex) | complex | 2.733 | 1.33E–12 |
| NFΚB1 | transcription regulator | 2.294 | 3.99E–12 |
| IL1A | cytokine | 4.207 | 4.53E–11 |
| E. coli B5 LPS | chemical - endogenous non-mammalian | 3.601 | 7.91E–08 |
| REL | transcription regulator | 2.279 | 3.92E–06 |
| NFκB1-RelA | complex | 3.225 | 1.72E–05 |
| TLR3 | transmembrane receptor | 2.357 | 4.62E–05 |
| TNFSF14 | cytokine | 3.023 | 7.08E–05 |
| TLR4 | transmembrane receptor | 2.379 | 7.79E–05 |
| TNFRSF13B | transmembrane receptor | 2.043 | 2.36E–03 |
| TNFRSF1B | transmembrane receptor | 2.575 | 4.41E–03 |
| NFκB (family) | group | 2.151 | 7.72E–03 |
| TNFRSF14 | transmembrane receptor | 2 | 1.08E–02 |
| NFκB-RelA | complex | 2.185 | 2.14E–02 |
| Lymphotoxin | complex | 2.219 | 7.30E–02 |
| MAP3K14/NIK | kinase | 3.046 | 1.22E–01 |
The significantly activated NF-κB-related upstream regulators predicted based on genes that were significantly deregulated in BRAF-mutated PTCs compared to healthy thyroid tissue are shown. The 9 upstream regulators which are components of the NF-κB pathways are indicated in bold. The 16 upstream regulators signaling toward the NF-κB pathways are indicated in italic. The z-score >2 indicates the possible activation of the molecule based on prior knowledge stored in the Ingenuity Knowledge Base. The p value indicates the significance based on the overlap between dataset genes and known targets regulated by the molecule.