Cancer Progress and Priorities: Gastric Cancer—Reply

We thank Tavakkoli et al. for their interest in our recent review of gastric cancer progress and priorities (1), which included discussion of the higher gastric cancer incidence rates among all racial and ethnic minorities compared to non-Hispanic Whites, and specifically higher mortality rates among Black and Hispanic non-cardia gastric cancer patients. We concluded that persistent disparities in incidence and mortality warrant risk-stratified prevention and interception strategies. We recognize the point raised by Tavakkoli et al. that, while we also reviewed the trend of increasing incidence of early-onset non-cardia gastric cancer among non-Hispanic White women, we did not acknowledge the mounting evidence of a similar trend among Hispanic White persons in the United States. We greatly appreciate Tavakkoli et al. bringing our attention to this important aspect of the changing demographics of early-onset non-cardia gastric cancer, and the need for additional research to understand, and ultimately prevent, this highly fatal disease that disproportionately affects racial and ethnic minorities.