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. 2023 Nov 9;98:104864. doi: 10.1016/j.ebiom.2023.104864

Table 1.

Estimated 2020 reductions in antibiotic courses prescribed to treat pharyngitis among children (5-14 years-old) under two scenarios of the impact of global Strep A vaccine implementation.

Scenario Assumptions Prescriptions averted (percent of prescriptions averted among total antibiotic courses for pharyngitis)
  • 1

    No change in prescribing practices (minimum estimate of averted prescriptions)

 Vaccination averts a proportion of sore throat prescriptions attributable to Strep A infection 2.8 million (32%)
  • 2

    Change in prescribing practices in HICs; no change in LMICs

 In HICsa 7.3 million (91%)
In LMICsb 0.2 million (32%)
Total 7.5 million (87%)

Bolded figures represent the total prescriptions averted for each scenario.

a

In high-income countries (HICs), prescribing practices for sore throat will be reduced to match the HIC with the lowest observed prescribing rate among children (the Netherlands; 1.4 courses per 100 persons per year) and, subsequently, a proportion of sore throat prescriptions that are attributable to Strep A infection will be averted by vaccination.

b

In low- and middle-income countries (LMICs), only a proportion of sore throat prescriptions that are attributable to Strep A infection will be averted by vaccination.