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PLOS Global Public Health logoLink to PLOS Global Public Health
. 2023 Nov 22;3(11):e0002595. doi: 10.1371/journal.pgph.0002595

South Africa’s male homicide epidemic hiding in plain sight: Exploring sex differences and patterns in homicide risk in a retrospective descriptive study of postmortem investigations

Richard Matzopoulos 1,2,*, Megan R Prinsloo 1,2,3, Shibe Mhlongo 4, Lea Marineau 5, Morna Cornell 6, Brett Bowman 7, Thakadu A Mamashela 8, Nomonde Gwebushe 9, Asiphe Ketelo 4, Lorna J Martin 10, Bianca Dekel 4, Carl Lombard 9,11, Rachel Jewkes 4,12, Naeemah Abrahams 4,13
Editor: Alok Atreya14
PMCID: PMC10664949  PMID: 37992033

Abstract

South Africa has an overall homicide rate six times the global average. Males are predominantly the victims and perpetrators, but little is known about the male victims. For the country’s first ever study on male homicide we compared 2017 male and female victim profiles for selected covariates, against global average and previous estimates for 2009. We conducted a retrospective descriptive study of routine data collected through postmortem investigations, calculating age-standardised mortality rates for manner of death by age, sex and province and male-to-female incidence rate ratios with 95% confidence intervals. We then used generalised linear models and linear regression models to assess the association between sex and victim characteristics including age and mechanism of injury (guns, sharp and blunt force) within and between years. 87% of 19,477 homicides in 2017 were males, equating to seven male deaths for every female, with sharp force and firearm discharge being the most common cause of death. Rates were higher among males than females at all ages, and up to eight times higher for the age group 15–44 years. Provincial rates varied overall and by sex, with the highest comparative risk for men vs. women in the Western Cape Province (11.4 males for every 1 female). Male homicides peaked during December and were highest during weekends, underscoring the prominent role of alcohol as a risk factor. There is a massive, disproportionate and enduring homicide risk among South African men which highlights their relative neglect in the country’s prevention and policy responses. Only through challenging the normative perception of male invulnerability do we begin to address the enormous burden of violence impacting men. There is an urgent need to address the insidious effect of such societal norms alongside implementing structural interventions to overcome the root causes of poverty, inequality and better control alcohol and firearms.

Introduction

In South Africa, injury-related mortality accounted for 8.6% of deaths in 2009 [1] primarily due to extremely high homicide rates, which were nearly six times the global average [2, 3]. Adult men, age 20 years and older, accounted for more than three-quarters (79%) of all homicides in which the age of the decedent was known [2]. Despite this significant difference, there has been limited focus on the male victims of homicide. Previously, two nationally conducted homicide studies in 1999 and 2009 explored the situational contexts of homicide, but only for women and children victims [4, 5]. This is consistent with global directives such as the 67th World Health Assembly Resolution that have prioritised preventive efforts to reduce violence against women regardless of the higher prevalence and proportion of victims being male. Globally men bear a far higher injury mortality and morbidity burden than women, [6] yet we were unable to identify any studies that explored the different patterns of male and female homicide in South Africa.

To address this gap, the South African Medical Research Council (SAMRC) funded a comprehensive Female and Male Homicide and Injury Mortality Study (FAMHIS) for 2017. The first phase included a nationally representative all-cause injury mortality study. A second phase was specifically designed to collect more detailed information from interviews with police investigating officers. This replicates female homicide studies conducted in 1999 and 2009, [4, 5] and, for the first time, provides comparable information describing the personal and situational risks for male victims.

The objective of our study was to compare (1) male and female victim profiles by external cause, age, province, day of week, month and alcohol-relatedness and (2) male: female homicide rate ratios against global averages for selected covariates (external cause and age), and (3) explored whether the odds of male versus female homicide by external cause and age had changed between 2009 and 2017.

Methods

Study design and data sources

We conducted a retrospective descriptive study of routine postmortem investigation data via a nationally representative survey of mortuaries sampled from eight of South Africa’s nine provinces for all deaths in 2017. Data were obtained from postmortem reports and ancillary documentation, including police reports and hospital records. For the ninth province, the Western Cape Province, the survey data were combined with compatible routinely captured data from the provincial Forensic Pathology Service (FPS), which maintains these data for all 16 medico-legal mortuaries in the province.

Sampling

We drew a multistage stratified cluster sample for eight provinces, using mortuaries as the primary sampling unit (cluster). We used a sampling frame of 58,641 postmortem reports from 121 mortuaries to draw a representative sample stratified by province and mortuary size: small (≤500 cases), medium (501–1500 cases) and large (>1500 cases). Sixty-five mortuaries from eight provinces were selected with an expected sample of 22,733 records. Fieldwork was conducted from 20 January to 3 July 2020. To account for the selection probabilities of mortuaries within survey strata, we applied analysis weights. In total 22,822 deaths were included in the survey, which exceeded the expected sample by 89 cases. For the ninth province (Western Cape Province) we appended 8174 records obtained from the provincial FPS. After application of sample weights total deaths due to injury were estimated at 54,734. Further details on sampling, fieldwork and data collection methods are provided elsewhere [7].

Case selection and variables

Information collected from the postmortem report included age and sex of the deceased and date, external cause and apparent manner of death and blood alcohol concentration. Sex was inferred from the biological sex recorded in the postmortem report. Blood alcohol was analysed using gas chromatography with flame ionization detection method. We excluded all deaths from natural causes, foetal deaths and deaths that occurred outside South Africa. For deaths due to external causes, we excluded suicide and deaths that were transport-related or unintentional after redistributing deaths due to undetermined intent. For all homicides we ascribed an external cause of death consistent with the tenth revision of the International Statistical Classification of Diseases and Related Health Problems, 2007 (ICD-10; S1 Table). We defined weekends as Saturdays and Sundays and hot months as November through March. The mortuary death register number and death notification number were collected as identifiers for follow-up, and to resolve data capture errors, but were excluded from the analysis.

Statistical analysis

We calculated age-standardised homicide rates (ASHR) by sex using 2017 population estimates provided by Dorrington (2013) [8] and the World Health Organization’s (WHO’s) world standard population, and male-to-female incidence rate ratios (IRRs) with 95% confidence intervals (CIs). Cases with unknown age were proportionally redistributed for males and females as follows:

ASHRr=sASHRe
ands=ttu

where ASHRr = ASHR with unknown age cases redistributed;

ASHRe = ASHR with unknown age cases excluded;

s = scaling factor; t = total number of homicides; u = homicides with unknown age

Similarly, we applied scaling factors to calculate adjusted homicide rates for comparison with the Global Burden of Disease study, which redistributes injury deaths in which the cause is unknown [7] by proportionally distributing these injury deaths to apparent manner of death (homicide, suicide and transport and other unintentional) by age and sex.

We used generalised linear models and linear regression models to assess the association between sex and victim characteristics including age and mechanism of injury (guns, sharp and blunt force) within and between the current survey (2017) and the 2009 study, [2] which used sampling methods that were comparable at a national level. Coefficients or relative risk (RR) and 95% confidence intervals (CIs) were reported. The models also included interaction terms between gender and year to compare males’ and females’ homicide characteristics between the two years; p values were reported and associations assessed using a significance level of alpha = 0.05.

Ethics

Ethical approval for the study was granted by the Ethics Committee of the SAMRC (EC 008-5-2018). Further approval and permission to access data were obtained from the National and Provincial Departments of Health and Forensic Pathology Service.

Results

A total of 19,477 injury deaths were due to homicide, representing 36% of all injury deaths. Males accounted for 87% of homicides (Table 1). Men had a much higher age standardised homicide rate than women (59.7 vs. 9.0 per 100,000 population), equivalent to 7 male deaths for every 1 female death.

Table 1. Descriptive male and female homicide victim characteristics in South Africa in 2017 by external cause of death, age, province, population group, month of year, day of week and alcohol-relatedness (weighted).

Male M/F Incidence Rate Ratio (95% CI) Female
Number (95%CI) Percentage (95%CI)** Age-standardised rate/100 000 population (95%CI)* Number (95%CI) Percentage (95%CI)** Age-standardised rate/100 000 population (95%CI)*
All homicides (n = 19477) * 16835 (15735, 17936) 86.7 (86.2, 87.2) 59.7 (55.5, 63.9) 6.9 (6.4, 7.4) 2583 (2351, 2814) 13.3 (12.8, 13.8) 9.0 (7.8, 10.1)
External cause (n = 19477) *** 16835 (15735, 17936) 2583 (2351, 2814)
    Sharp force 7071 (6560, 7582) 42.0 (40.5, 43.5) 24.4 (22.3, 26.6) 8.4 (7.5, 9.5) 885 (771, 999) 34.3 (32.5, 36.1) 3.1 (2.4, 3.7)
    Firearm discharge 5616 (4955, 6278) 33.4 (31.3, 35.5) 20.1 (17.4, 22.9) 9.0 (7.8, 10.3) 659 (609, 708) 25.5 (23.9, 27.2) 2.3 (1.9, 2.7)
    Blunt force 3111 (2940, 3282) 18.5 (17.0, 20.1) 11.3 (10.2, 12.4) 6.0 (5.1, 7.0) 546 (496, 595) 21.1 (19.8, 22.6) 1.9 (1.5, 2.3)
    Strangled/asphyxiated/suffocated 212 (183, 241) 1.3 (1.1, 1.4) 0.8 (0.6, 1.1) 1.0 (0.7, 1.3) 232 (201, 263) 9.0 (8.1, 10.0) 0.8 (0.5, 1.1)
    Fire /other burn 125 (90, 160) 0.7 (0.6, 1.0) 0.5 (0.2, 0.8) 3.1 (1.7, 5.5) 43 (32, 55) 1.7 (1.2, 2.3) 0.2 (0.1, 0.2)
    Other**** 180 (98, 262) 1.1 (0.7, 1.6) 0.6 (0.2, 1.0) 1.6 (1.1, 2.3) 122 (77, 167) 4.7 (3.5, 6.4) 0.4 (0.3, 0.5)
    Unknown***** 520 (435, 606) 3.1 (2.5, 3.8) 3.0 (0.8, 5.3) 5.7 (3.9, 8.2) 96 (74, 118) 3.7 (2.9, 4.7) 0.3 (0.1, 0.6)
Age in years (n = 18984) 16465 (15513, 17416) 2506 (2304, 2708)
    0–4 153 (102, 204) 0.9 (0.7, 1.2) 5.3 (4.4, 6.1) 1.8 (1.1, 2.8) 84 (47, 121) 3.4 (2.3, 4.9) 3.0 (2.3, 3.6)
    5–14 122 (101, 143) 0.7 (0.6, 0.9) 2.3 (1.9, 2.8) 1.7 (1.1, 2.8) 70 (56, 85) 2.8 (2.3, 3.4) 1.4 (1.0, 1.7)
    15–29 7621 (7184, 8058) 46.3 (45.6, 47.0) 101.2 (98.9, 103.4) 8.4 (7.4, 9.4) 898 (817, 979) 35.8 (34.4, 37.3) 12.1 (11.3, 12.9)
    30–44 6012 (5595, 6429) 36.5 (35.9, 37.2) 93.0 (90.6, 95.4) 7.9 (6.9, 9.0) 760 (673, 846) 30.3 (28.9, 32.0) 11.8 (10.9, 12.6)
    45–59 1894 (1775, 2012) 11.5 (10.9, 12.1) 55.4 (52.9, 57.9) 5.9 (4.9, 7.0) 387 (338, 437) 15.5 (13.6, 17.5) 9.5 (8.5, 10.4)
    60–69 461 (417, 505) 2.8 (2.5, 3.1) 37.3 (33.9, 40.7) 3.8 (2.8, 5.2) 162 (142, 182) 6.5 (5.6, 7.4) 9.8 (8.3, 11.3)
    70–79 163 (137, 190) 1.0 (0.8, 1.2) 30.2 (25.6, 34.8) 3.3 (2.1, 5.2) 79 (64, 93) 3.1 (2.7, 3.7) 9.1 (7.1, 11.1)
    80+ 39 (25, 52) 0.2 (0.2, 0.3) 19.1 (13.1, 25.1) 1.3 (0.7, 2.6) 66 (47, 84) 2.6 (1.9, 3.6) 14.5 (11.0, 18.1)
    Mean age (SD) 32.5 (12.7) 36.4 (17.5)
Province (n = 19477) 16835 (15735, 17936) 2583 (2351, 2814)
    Eastern Cape 2841 (2667, 3016) 16.9 (15.5, 18.3) 97.2 (85.6, 108.8) 5.4 (4.7, 6.3) 599 (541, 657) 23.2 (20.6, 26.0) 17.5 (12.0, 22.9)
    Free State 960 (819, 1100) 5.7 (4.9, 6.6) 69.5 (54.9, 84.2) 7.2 (5.3, 9.7) 143 (111, 176) 5.6 (4.4, 7.0) 10.0 (5.8, 14.2)
    Gauteng 3812 (2859, 4764) 22.6 (18.5, 27.4) 47.0 (29.9, 64.1) 6.9 (5.9, 8.0) 539 (346, 731) 20.9 (15.5, 27.5) 7.0 (2.7, 11.4)
    Kwazulu Natal 3703 (3268, 4138) 22.0 (19.7, 24.5) 73.6 (60.9, 86.3) 6.7 (5.8, 7.7) 608 (512, 705) 23.6 (20.3, 27.2) 10.9 (8.2, 13.7)
    Limpopo 640 (465, 815) 3.8 (2.9, 5.0) 27.0 (14.8, 39.3) 6.8 (4.8, 9.7) 108 (70, 146) 4.2 (3.1, 5.6) 3.7 (0.8, 6.6)
    Mpumalanga 581 (469, 693) 3.5 (2.8, 4.2) 26.7 (18.7, 34.7) 5.2 (3.7, 7.2) 118 (91, 145) 4.6 (3.7, 5.7) 5.1 (2.5, 7.8)
    Northern Cape 211 (107, 314) 1.3 (0.8, 2.0) 39.2 (0.0, 80.6) 4.7 (2.7, 8.1) 46 (23, 70) 1.8 (1.1, 3.0) 8.7 (0.0, 20.0)
    Northwest 628 (517, 739) 3.7 (3.1, 4.5) 32.2 (19.7, 44.7) 5.8 (4.1, 8.2) 105 (102, 108) 4.1 (3.7, 4.5) 5.8 (3.4, 8.2)
    Western Cape 3460 (3460, 3460) 20.6 (19.2, 21.9) 100.7 (100.7, 100.7) 11.4 (9.4, 13.9) 316 (316, 316) 12.2 (11.1, 13.4) 9.2 (8.8, 9.5)
Month of year (n = 19443) 16808 (15708, 17909) 2582 (2350, 2813)
    January 1170 (1104, 1236) 7.0 (6.7, 7.3) 4.3 (3.7, 4.8) 6.7 (5.2, 8.8) 183 (143, 224) 7.1 (5.4, 9.3) 0.6 (0.5, 0.8)
    February 1168 (1088, 1248) 6.9 (6.7, 7.2) 4.4 (3.9, 4.9) 6.7 (5.1, 8.7) 184 (157, 211) 7.1 (6.2, 8.1) 0.6 (0.4, 0.9)
    March 1378 (1286, 1471) 8.2 (7.7, 8.7) 5.1 (4.3, 5.9) 6.7 (5.3, 8.6) 215 (193, 237) 8.3 (7.5, 9.2) 0.8 (0.5, 1.0)
    April 1579 (1480, 1679) 9.4 (9.0, 9.8) 5.7 (5.0, 6.4) 6.3 (5.1, 7.9) 263 (220, 307) 10.2 (9.0, 11.5) 0.9 (0.6, 1.2)
    May 1266 (1152, 1380) 7.5 (7.2, 7.9) 4.7 (3.9, 5.6) 5.7 (4.5, 7.2) 234 (177, 291 9.1 (7.6, 10.8) 0.8 (0.5, 1.1)
    June 1205 (1072, 1339) 7.2 (6.8, 7.6) 4.4 (3.7, 5.1) 7.0 (5.4, 9.1) 181 (135, 227) 7.0 (5.8, 8.4) 0.6 (0.4, 0.8)
    July 1514 (1359, 1670) 9.0 (8.6, 9.5) 5.7 (4.8, 6.7) 7.0 (5.5, 8.9) 227 (192, 263) 8.8 (8.0, 9.6) 0.8 (0.5, 1.0)
    August 1264 (1178, 1351) 7.5 (7.3, 7.8) 4.6 (4.0, 5.3) 7.2 (5.5, 9.3) 185 (149, 222) 7.2 (6.2, 8.3) 0.6 (0.5, 0.8)
    September 1519 (1403, 1635) 9.0 (8.7, 9.4) 5.6 (4.7, 6.5) 7.2 (5.7, 9.2) 221 (201, 241) 8.6 (7.9, 9.3) 0.8 (0.5, 1.0)
    October 1395 (1310, 1480) 8.3 (7.9, 8.7) 5.3 (4.4, 6.2) 7.2 (5.6, 9.2) 205 (174, 235) 7.9 (7.2, 8.7) 0.7 (0.4, 1.0)
    November 1455 (1326, 1585) 8.7 (8.3, 9.0) 5.4 (4.6, 6.2) 7.0 (5.5, 8.9) 219 (197, 241) 8.5 (7.7, 9.3) 0.8 (0.5, 1.0)
    December 1894 (1756, 2032) 11.3 (10.9, 11.7) 7.0 (6.0, 7.9) 7.6 (6.1, 9.4) 264 (239, 289) 10.2 (9.1, 11.5) 0.9 (0.7, 1.2)
Day of week (n = 19443) 16808 (15708, 17909) 2582 (2350, 2813)
    Monday 2123 (1979, 2267) 12.6 (12.2, 13.1) 8.0 (6.9, 9.1) 5.6 (4.7, 6.8) 397 (341, 453) 15.4 (14.2, 16.6) 1.4 (1.0, 1.7)
    Tuesday 1640 (1477, 1803) 9.8 (9.3, 10.3) 6.3 (5.2, 7.3) 5.2 (4.3, 6.4) 331 (284, 379) 12.8 (11.8, 13.9) 1.2 (0.8, 1.5)
    Wednesday 1564 (1452, 1676) 9.3 (8.7, 9.9) 5.9 (5.0, 6.8) 5.1 (4.2, 6.3) 320 (285, 356) 12.4 (10.9, 14.1) 1.1 (0.7, 1.5)
    Thursday 1505 (1378, 1631) 9.0 (8.7, 9.2) 5.9 (5.0, 6.8) 5.7 (4.6, 7.1) 279 (235, 324) 10.8 (9.8, 12.0) 1.0 (0.6, 1.3)
    Friday 1918 (1751, 2084) 11.4 (11.0, 11.8) 7.2 (6.1, 8.2) 8.2 (6.5, 10.2) 247 (217, 277) 9.6 (8.7, 10.5) 0.9 (0.6, 1.2)
    Saturday 3763 (3508, 4018) 22.4 (21.7, 23.1) 13.6 (11.9, 15.2) 9.3 (7.9, 11.1) 424 (356, 491) 16.4 (14.9, 18.1) 1.5 (1.1, 1.8)
    Sunday 4296 (4005, 4588) 25.6 (24.9, 26.2) 15.5 (14.0, 16.9) 7.8 (6.7, 9.0) 583 (531, 635) 22.6 (20.5, 24.8) 2.0 (1.5, 2.5)
Blood Alcohol Concentration (n = 3363) *******
    Positive BAC 1626 (1152, 2099) 54.8 (53.2, 56.3) 5.6 (4.2, 7.0) 11.4 (8.6, 15.2) 150 (89, 211) 38.2 (37.1, 39.3) 0.5 (0.3, 0.7)
    Mean positive g/100ml (SD; range) 0.09 (0.10; 0.00, 0.49) 0.06 (0.08; 0.00, 0.46)

* Column totals do not always sum to n due to 59 cases where sex was recorded as ‘undetermined’. All rates, except rates for age in years, are age standardised.

** Row percentages are displayed for “All homicide” and column percentages for covariates.

*** Postmortem reports specified a primary cause of death for each death, which we assigned as the external cause. In addition, we noted 2833 cases with multiple injuries, of which 2426 were male, 405 female and 2 unknown.

**** Includes, for males: neglect and abandonment (102 cases), poisoning (45 cases), being pushed from a height (11 cases), drowning/ immersion (9 cases), crushing (2 cases), electrocution (3 cases), and assault by other specified means 8 cases). For females: neglect and abandonment (70 cases), poisoning (21 cases), drowning/ immersion (4 cases), being pushed from a height (2 cases), electrocution (2 cases), maternal deaths/abortion related (5 cases), and assault by other specified means (18 cases).

***** Unknown includes assault by other unspecified means.

****** Blood alcohol results based on the observed data without any adjustment or imputation for missing data (83% of all data)

The most common external causes of death were sharp force, firearm discharge and blunt force injuries, with significantly higher rates among men than women (24.4, 20.1 and 11.3 vs 3.1, 2.3 and 1.9/100,000 respectively). Proportionally, more women died due to strangulation or asphyxiation than men (8.9% vs 1.2%), but rates were equivalent.

Men had far higher homicide rates than women in all age groups, specifically among the age group 15–29 (101.2 vs 12.1/100,000 population) and 30–44 (93.0 vs 11.8/100,00 population) years, equating to 8.4 and 7.9 males for every female death in these age groups respectively.

There was considerable interprovincial variation by sex: three to four times higher in the provinces with the highest homicide rates compared to provinces with the lowest rates among both males and females. For males age-standardised homicide rates ranged from 26.7 in Mpumalanga to 100.7/100,000 in the Western Cape; for females the lowest homicide rates were recorded in Limpopo (3.7 per 100,000 population) and the highest in the Eastern Cape (17.5). The male age-standardised homicide rates in the Western Cape were significantly higher than all provinces except the Eastern Cape, which were in turn significantly higher than all other provinces except KwaZulu-Natal. The highest male:female incidence rate ratio (IRR) was recorded in the Western Cape with 11.4 males for every female homicide.

There was also considerable interprovincial variation in the external cause of homicide by sex, particularly for firearm homicides, 88% of which occurred in four provinces (Eastern Cape, KwaZulu Natal, Gauteng and the Western Cape). Sharp force injuries were the leading cause of male homicide in all provinces except Gauteng and the Western Cape, where firearms were the leading cause. For females, sharp force was the leading cause of homicide in all provinces except Mpumalanga.

Temporally, both sexes followed a similar pattern with the highest percentage of cases coinciding with festive periods–December (Christmas) and April (Easter)– and school holidays–July and September. Almost half of the cases were recorded on weekend days compared with weekdays. Disproportionately more men than women were murdered on week and weekend days, particularly on Saturdays (9.3 male deaths for every 1 female death). Rates on Mondays were higher than on other week days. A significantly higher percentage of male homicide victims tested positive for blood alcohol than females (11.4 males for 1 female).

Overall homicide rates could be more than 12% higher than shown in Table 1. Adjusting the age standardised and age specific rates by apportioning additional injury deaths of undetermined intent (Table 2), the overall adjusted homicide rate in South Africa was 7.1 times the global average, and higher among males than females (7.4 vs 5.9 times the global average respectively). There was considerable variation by external cause and age. Notably, IRRs for sharp force injuries amongst males and females were considerably higher than global averages (12.0 and 7.4 times respectively). For males, the highest IRRs were recorded amongst young adults aged 25–34 years, with homicide rates over eight times the global average. For females IRRs were highest in the older age categories, peaking at 10.9 among women older than 70 years.

Table 2. Male and female homicide rates in South African 2017 mortuary survey (weighted), compared to global rates from the Global Burden of Disease (GBD) study, 2017, [9] by external cause of death and age.

Male Female Overall
Mortuary Survey (MS) MS Adjusted*
(1)
GBD
(2)
MS(1):
GBD(2)
IRR
MS MS Adjusted*
(1)
GBD
(2)
MS(1):
GBD(2)
IRR
MS MS Adjusted*
(1)
GBD
(2)
MS(1):
GBD(2)
IRR
Age-standardised rate/100 000 population (95%CI) Ratio Age-standardised rate/100 000 population (95%CI) Ratio Age-standardised rate/100 000 population (95%CI) Ratio
All homicide (n = 19477) 59.7 (55.5, 63.9) 66.0 (60.8, 71.2) 8.9 (8.4, 9.5) 7.4 9.0 (7.8, 10.1) 10.6 (9.1, 11.4) 1.8 (1.7, 2.0) 5.9 34.0 (31.6, 36.4) 38.2 (35.2, 41.2) 5.4 (5.1, 5.7) 7.1
    Firearm discharge 20.1 (17.4, 22.9) 22.2 (19.1, 25.5) 4.2 (4.0, 4.4) 5.3 2.3 (1.9, 2.7) 2.7 (2.2, 3.1) 0.5 (0.5, 0.5) 5.4 11.0 (9.6, 12.4) 12.4 (10.7, 14.0) 2.3 (2.2, 2.5) 5.4
    Sharp force 24.4 (22.3, 26.6) 27.0 (24.4, 29.6) 2.1 (1.7, 2.3) 12.9 3.1 (2.4, 3.7) 3.7 (2.8, 4.2) 0.5 (0.4, 0.5) 7.4 13.9 (12.6, 15.2) 15.6 (14.0, 17.2) 1.3 (1.1, 1.4) 12.0
    Other** 15.1 (13.4, 16.8) 16.7 (14.7, 18.7) 2.6 (2.4, 2.9) 6.4 3.6 (3.0, 4.3) 4.2 (3.5, 4.9) 0.9 (0.8, 1.0) 4.7 9.3 (8.4, 10.2) 10.5 (9.4, 11.5) 1.8 (1.6, 1.9) 5.8
Age-specific rate/ 100 000 population (95% CI) Ratio Age-specific rate/ 100 000 population (95% CI) Ratio Age-specific rate/ 100 000 population (95% CI) Ratio
Age in years (n = 18984)
    0–14 3.4 (3.0, 3.8) 4.1 (3.6, 4.6) 1.5 (1.2, 1.8) 2.7 1.9 (1.6, 2.2) 2.5 (2.1, 2.9) 1.1 (0.9, 1.3) 2.3 2.7 (2.4, 2.9) 3.4 (3.0, 3.6) 1.3 (1.1, 1.5) 2.6
    15–19 49.8 (46.9, 52.7) 52.1 (48.7, 55.5) 10.9 (9.9, 12.0) 4.8 7.0 (5.9, 8.0) 8.2 (6.8, 9.5) 1.8 (1.7, 2.1) 4.6 28.2 (26.7, 29.8) 30.3 (28.5, 32.3) 6.5 (5.9, 7.1) 4.7
    20–24 120.4 (116.1, 124.7) 126.7 (121.5, 131.8) 17.8 (16.7, 19.0) 7.1 12.9 (11.5, 14.3) 14.7 (12.9, 16.5) 2.4 (2.2, 2.7) 6.1 66.3 (64.0, 68.5) 70.7 (67.9, 73.4) 10.2 (9.6, 10.9) 6.9
    25–29 131.5 (127.1, 135.8) 139.6 (134.3, 144.8) 16.3 (15.3, 17.4) 8.6 15.3 (13.8, 16.7) 17.3 (15.3, 19.1) 2.3 (2.1, 2.6) 7.5 72.9 (70.7, 75.2) 78.1 (75.4, 80.9) 9.4 (8.8, 10.0) 8.3
    30–34 114.1 (109.9, 118.2) 121.9 (116.8, 126.8) 15.3 (14.4, 16.3) 8.0 13.0 (11.6, 14.3) 14.8 (13.0, 16.5) 2.4 (2.2, 2.6) 6.2 63.1 (60.9, 65.2) 68.1 (65.4, 70.7) 8.9 (8.4, 9.5) 7.7
    35–39 88.1 (84.0, 92.1) 96.7 (91.6, 101.8) 14.1 (13.3, 15.0) 6.9 11.0 (9.6, 12.5) 12.6 (10.8, 14.6) 2.3 (2.1, 2.5) 5.5 49.2 (47.1, 51.4) 54.4 (51.8, 57.2) 8.2 (7.8, 8.8) 6.6
    40–44 69.1 (65.3, 73.0) 74.8 (70.2, 79.6) 12.0 (11.4, 12.9) 6.2 10.8 (9.2, 12.3) 12.3 (10.3, 14.3) 2.2 (2.1, 2.4) 5.6 40.6 (38.4, 42.7) 44.4 (41.7, 47.0) 7.2 (6.8, 7.6) 6.2
    45–49 56.9 (53.1, 60.6) 63.3 (58.5, 68.0) 10.0 (9.4, 10.6) 6.3 10.9 (9.1, 12.6) 12.2 (10.0, 14.4) 2.0 (1.9, 2.1) 6.1 35.4 (33.2, 37.5) 39.5 (36.7, 42.2) 6.0 (5.7, 6.4) 6.6
    50–69 35.3 (33.5, 37.1) 40.6 (38.3, 43.0) 7.8 (7.4, 8.2) 5.2 12.2 (11.0, 13.4) 14.4 (12.8, 16.0) 1.9 (1.8, 2.0) 7.6 25.1 (24.0, 26.3) 29.1 (27.7, 30.7) 4.8 (4.6, 5.0) 6.1
    70+ 15.4 (13.3, 17.5) 18.2 (15.4, 21.0) 5.0 (4.7, 5.4) 3.6 19.4 (16.2, 22.5) 22.9 (18.8, 27.0) 2.1 (1.9, 2.2) 10.9 16.8 (15.0, 18.6) 19.8 (17.5, 22.2) 3.4 (3.2, 3.6) 5.8
    Mean age (SD) 32.5 (12.7) 36 (17.5) 33.0 (13.6)

* Adjusted for undetermined cause of unnatural death as presented in Prinsloo et at (2021).

** Includes blunt force, strangled/asphyxiated/suffocated, being pushed from a height, drowning/immersion, poisoning from ingestion, poisoning from gas, fire or other burn, neglect and abandonment, maternal death/ abortion related, crushing, electrocution, assault by other specified means, and unknown cases.

Male victims were on average four years younger than females in 2009 and 2017 (Table 3).

Table 3. Comparison of homicide characteristics between 2009 and 2017 by sex and effect measure of study year and sex.

Characteristic  Male Female Effect measure of study year and sex
  Sex, RR (95% CI) p value
2009 2017 2009 2017 2009 2017
Age, median (IQR) 29.0 (23.0, 39.0) 30.0 (24.0, 38.0) 34.0 (23.0, 47.0) 32.0 (24.0, 47.0) Female: 1.00 Female: 1.00  
          Male: -4.08 (-4.92, -3.24)* Male: -3.84 (-4.84, -2.83)* 0.711
Died from sharp force injuries, percent (95% CI) 43.8 (41.1, 46.5) 42.0 (40.5, 43.5) 30.0 (27.7, 32.5) 34.2 (32.5, 36.1) Female: 1.00 Female: 1.00  
          Male: 1.46 (1.36, 1.56) Male: 1.23 (1.16, 1.30) <0.001
Died from gunshot injuries, percent (95% CI) 30.1 (27.6, 32.7) 33.4 (31.3, 35.5) 22.3 (20.0, 24.9) 25.5 (23.9, 27.2) Female: 1.00 Female: 1.00  
          Male: 1.35 (1.27, 1.44) Male: 1.31 (1.17, 1.46) 0.613
Died from blunt force injuries, percent (95% CI) 22.1 (20.9, 23.5) 18.5 (17.0, 20.1) 26.8 (24.8, 29.0) 21.1 (19.7, 22.5) Male: 1.00 Male: 1.00  
          Female: 1.21 (1.12, 1.31) Female: 1.14 (1.04, 1.24) 0.295
Died on a weekend, percent (95% CI) 46.0 (44.9, 47.1) 48.0 (46.8, 49.1) 37.6 (35.5, 39.7) 39.0 (37.1, 40.9) Female: 1.00 Female: 1.00  
Male: 1.22 (1.16, 1.29) Male: 1.23 (1.17, 1.29) 0.885
Died during hot season, percent (95% CI) 42.9 (41.8, 44.0) 42.0 (41.4, 42.7) 42.7 (40.6, 44.8) 41.3 (37.3, 45.4) Female: 1.00 Female: 1.00
          Male: 1.01 (0.96, 1.05) Male: 1.02 (0.93, 1.12) 0.788

* coefficient

Males had a significantly higher risk of being killed by sharp force than females in both 2009 and 2017 [RR = 1.46 (9% CI: 1.36, 1.56) vs RR = 1.23 (95% CI: 1.16, 1.46)] respectively. This represented a significant decrease in risk for males and a corresponding increase for females between years. The risk of dying from gunshot injuries increased for both men and women in this period, and was higher for men than women in both 2009 and 2017 [RR = 1.35 (9% CI: 1.27, 1.44) vs RR = 1.31 (95% CI: 1.17, 1.46) respectively. Female risk was higher than men for blunt force injuries [RR = 1.21 (9% CI: 1.12, 1.31) in 2009 vs RR = 1.14 (95% CI: 1.04, 1.24) in 2017], with no change between years. Males had a significantly higher risk of dying on weekends than females in both years [RR = 1.22 (9% CI: 1.16, 1.29) vs RR = 1.23 (95% CI: 1.17, 1.29)] respectively, with no change over time. There were no significant differences by sex or year in homicide risk during the hot season.

Discussion

These findings confirm the enduring nature of South Africa’s problem of interpersonal violence in 2017 and the massive, disproportionate homicide risk borne by adult men. This hugely elevated risk was already reported in previous national estimates in which males accounted for 84% of homicides, and 86% in 2000 and 2009 respectively [2, 10]. Although homicide decreased from 2009 [2]–overall and amongst men and women–the decrease amongst men was proportionally smaller. This is consistent with global data showing that men bear a consistently higher share of homicide than women, [11] but in South Africa the male: female rate ratio is considerably greater. The disaggregated homicide pattern presented in this study is similar to countries in Latin America and the Caribbean with high overall homicide rates (>25 per 100,000 population), largely among men (>80%). Conversely, countries with low homicide rates (<5 per 100,000 population) have a lower proportion (<60%) of male homicides [6]. The fact that men are both perpetrators and victims of homicides masks the strong evidence that men are extremely vulnerable in many contexts. Responding to this inequity impacting men is complicated further by men frequently holding greater power in high violence settings and by targeted public health responses that continue to address violence only on women and children.

Although the risk of homicide was higher for men than women at all ages, age strongly predicted the risk of homicide, with victims being predominantly males between 15–44 years old, and the sex differential starting from a very young age. A previous national survey reported a five times higher homicide rate among boys than girls [12]. The risk factors for interpersonal violence in South Africa are well understood [13, 14]. However, a plethora of co-occurring factors exacerbates the risk of violence in South Africa, as it does in any other high violence setting. These include areas of lower socioeconomic status with greater economic disparities and legacies of colonialism, migrant labour, slavery, other forms of discrimination and human rights violations.

Whereas demographics also determine risk for homicide globally–highest among young adults and males–these risks in South Africa are compounded by socioeconomic factors with high concentrations of homicide in extremely poor neighbourhoods [15]. The country is among the world’s most unequal, [16] a legacy of the systemic violence of its post-colonial past, the migrant labour system for mines, and the recent history of racial segregation. Rapid urbanisation has also led to the development of large urban slums that lack the requisite physical and social infrastructure to facilitate social cohesion, with easy access to cheap alcohol [17]. Socially, violence has been normalised as a frequent feature of civil protest and political discourse, and the hegemonic form of masculinity is patriarchal. South Africa also has high levels of legal and illegal firearm ownership and the highest rates of incarceration–an additional exposure to institutional and interpersonal violence–in Africa, with a ratio of male to female prisoners that is double the global average [18]. Given these combination of factors, it is not surprising that this is a society in which interpersonal violence is often expected, and that the forms that it takes are highly gendered. Common reactions to adverse events tend to differ between men and women. Men are socialised into coping by externalising through anger, irritability, violence against intimate partners and others, and increased engagement in risk-taking behaviours [19]. This, alongside the high levels of violence to which males are exposed across the life course, [20] engenders a continuous, and often intergenerational cycle of violence.

South African data have consistently shown that men are not only the main perpetrators of violence, [5] they also have an overwhelmingly higher risk of violent death. Part of this may relate to prevailing gender norms in which men identify with the role of “protector” [21]. Defending honour and asserting dominance over others may increase men’s resistance in the face of conflict, in turn increasing the risk of fatal outcomes. This was shown in a recent South African study of co-occurring violence during robbery events in which male victims were significantly more at risk of a fatal outcome [22].

Violence against women is endemic in South Africa, with rates almost six times the global figures. South Africa has responded proactively to such violence with interventions and policy measures culminating in a National Strategic Plan on Gender-based Violence & Femicide, including measures to strengthen the criminal justice system, promote accountability across the state and support survivors. However, men’s disproportionate burden of homicide has not resulted in targeted, meaningful prevention. The number of female homicides decreased over time, while the number of male homicides, and hence their share of all homicide, increased from 2009 to 2017 [2]. Yet this has not changed the prevailing socially normative perception that men are neither vulnerable to, nor the victims of, trauma [20]. Ratele et al (2016) suggest that this limited engagement with evidence of men’s vulnerability has inadvertently pathologised black males in South Africa, and prevents us from recognising that boys and men are legitimate recipients of violence prevention interventions [23]. There is an urgent need for effective interventions that target men and address not only the gender norms that increase risk, but also the structural drivers of homicide that are rooted in poverty and socio-economic inequality.

In comparison with global averages, South African men, women and children were all exposed to abnormally high levels of homicide risk. Age-standardised homicide rates were similar in 2017 and 2009 [2]. However, the share of overall mortality due to homicide–ranked 8th and accounting for 3.5% of all-cause mortality in 2012 [3]–is set to rise as mortality from other major causes such as HIV continues to decrease, [24] while the share of homicide among all injury deaths is expected to rise due to a decrease in road deaths [7]. The global decline in homicide has also resulted in the relative risk of homicide in South Africa increasing from 5.8 to 7.1 times the global average from 2009 to 2017.

The male to female ratio was highest for firearm discharge, the second leading cause. The implementation of the Firearms Control Act was associated with reductions in firearm homicide, but poor enforcement is associated with a subsequent surge in gun deaths [25]. Males, who are also more likely to be armed, [22] accounted for the larger share of the increase in gun deaths reported between 2009 and 2017. The higher incidence of homicide on weekends and holidays affirmed the prominent role of alcohol, present in 55% of male and 38% of female homicide cases. South Africa’s drinking pattern is characterised by very high levels of heavy episodic drinking, particularly amongst males, which is reflected in the gender distribution of homicides attributable to alcohol. Males accounted for 95% of the estimated 15,168 alcohol attributable-homicides in South Africa in 2000, 2006 and 2012 [26]. Alcohol sales bans implemented alongside lockdowns during South Africa’s COVID-19 pandemic were associated with reductions in non-natural deaths and trauma cases, [27, 28] but this critical policy window has not, as yet, translated into a more sustained and proactive approach to reduce alcohol harms [29].

There was considerable interprovincial variation in overall homicide. While the homicide risk was higher for men than women in all provinces, the provinces with the highest male homicide rates also ranked highest for female homicide. This suggests violence is endemic in some provinces, which will require complex population-level approaches to prevention that address social determinants and norms that support violence. The temporal pattern, with the highest homicide incidence in months that coincided with school holidays and festive seasons, rather than the warmer months, did not support the theory that aggression (and with it homicide) is associated with increases in temperature [30]. The temperature range from winter to summer in South Africa may be insufficient to affect aggression levels, but further analysis should explore the potential confounding effect of alcohol consumption on the temporal pattern.

South Africa is one of the countries worldwide with a quadruple disease burden where injuries feature alongside major infectious and non-communicable diseases and the largest HIV pandemic worldwide. The burden is compounded by the deleterious effects of violence on other outcomes -mental health and developmental issues such as substance abuse, chronic conditions (e.g. gastrointestinal, gynaecological and fatigue-related), absenteeism and loss of work—and, moreover, is a major impediment to social development [31, 32]. Yet despite its importance among major causes of injury, there is no sense of urgency about addressing violence as a structural issue, and interventions and policies to reduce population-level homicide have been ineffective with the possible exception of intimate femicide, which has the focus of concerted prevention efforts over two decades [33].

With male violence frequently located in the public space, [22] there is potential to converge the prevention agenda to reduce male and female homicide jointly, which might give population-level approaches more impetus. This would also align with the Sustainable Development Goals (SDGs), which have substantially expanded the scope of violence prevention by advocating the reduction of ‘all forms of violence everywhere’ (Target 16.1), eventually–but only implicitly—recognising men as potential targets for prevention action. The urgent need to address violence against women and children should therefore be integrated into an inclusive approach to address violence in line with SDG16 [34].

There remains an urgent need for homicide and other violence indicators to be disaggregated by sex, to shed further light on socio-demographic-specific risk factors and situational pathways to homicide in various types of violence. This is not only the case in South Africa. The WHO explains the critical importance of disaggregating data for health systems, notably to provide information to allocate appropriate resources; yet the WHO itself only started reporting disaggregated global health statistics in 2019. The forthcoming male homicide study, the second phase of the current study, will be the first research to profile male victims and perpetrators.

The study has several limitations. The sample size was adequate for estimating population incidence rates in 2009 and 2017 at the national level, but the study lacked power to compare rates for certain subgroups between study years. In addition, the sampling frame was different between the two years, with a smaller sampling frame in 2009, devised to compare injury rates across metropolitan and non-metropolitan populations but limiting our ability to compare provincial homicide patterns. Another limitation was that with only two time points we could not test for trends in male homicide rates. The large number of cases missing blood alcohol data (83% of all cases) requires that these findings be interpreted with caution. Despite these limitations, our study demonstrates the value of mortuary-based survey data for estimating sex-disaggregated homicide data in the absence of routine injury mortality surveillance and confirms that this approach is feasible in a high violence, resource-limited setting.

Public health implications

Our study highlights the extraordinarily high levels of homicide in South Africa, the disproportionate burden borne by adult men, and the negligible evidence-based prevention response to date. We urgently need a redoubling of efforts to control alcohol and firearms, which have already been shown to influence rates of violence in South Africa, as well as programmes to address the insidious effect of societal norms that drive the excessive burden of physical violence borne by men, and structural interventions to overcome the root causes of poverty and inequality. We consider our study to be an important and necessary–if belated—first step to identify specific groups at increased homicide risk who could benefit from specific interventions and policies. Only through challenging the perceived invulnerability of males can we begin to address the enormous burden of violence borne by men.

Supporting information

S1 Table. External cause of homicide categories included in the injury-related mortality survey and corresponding ICD-10 codes, South Africa, 2017.

(DOCX)

S1 Text. Inclusivity in global research.

(DOCX)

Acknowledgments

We are grateful for the support of forensic pathology services across all provinces and, in particular, to Professor Emeritus Gert Saayman of the Faculty of Health Sciences, Dept of Forensic Medicine, University of Pretoria; Prof Jeanine Vellema, the Retired Head of the Clinical Department of the Gauteng Department of Health Forensic Pathology Service Southern Cluster and an Honorary Member of the University of the Witwatersrand Division of Forensic Medicine & Pathology; and Dr Sibusiso Ntsele of the eThekwini Forensic Pathology Services, KwaZulu-Natal Department of Health, Durban, South Africa.

Data Availability

Availability of data used in the study would be subject to permission by the Health Research Ethics Committee and provincial authorities that approved the original study. This is a recently completed study and the dataset will initially be used for capacity development among the emerging researchers on study team. Thereafter access to a de-identified dataset is available upon reasonable request. Requests should be sent to the convenor of the South African Medical Research Council’s Research Ethics Office, Ms Adri Labuschagne (Adri.Labuschagne@mrc.ac.za), for consideration. Guidelines for applications and related materials are available at: https://www.samrc.ac.za/research/rio-research-ethics-office A period of 24 months after publication of the main study results should elapse before requests are made, to allow the authors to publish sub-studies and further analyses.

Funding Statement

The study was funded by the South African Medical Research Council (42060 to RM) and the Ford Foundation (133505 to NA). RM, MP, SM, NG, AK, BD, CL, RJ and NA receive salaries from the SAMRC. This work was supported by the National Institutes of Health (U01AI069924 & R01 MH122308-01A1 to MC) and the Fogarty International Center and the National Institute of Mental Health (D43TW011308 to MC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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PLOS Glob Public Health. doi: 10.1371/journal.pgph.0002595.r001

Decision Letter 0

Alok Atreya

24 Jul 2023

PGPH-D-23-01105

South Africa’s male homicide epidemic hiding in plain sight: exploring sex differences and patterns in homicide risk in a retrospective descriptive study of postmortem investigations

PLOS Global Public Health

Dear Dr. Matzopoulos,

Thank you for submitting your manuscript to PLOS Global Public Health. After careful consideration, we feel that it has merit but does not fully meet PLOS Global Public Health’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please submit your revised manuscript by Sep 07 2023 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at globalpubhealth@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pgph/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

We look forward to receiving your revised manuscript.

Kind regards,

Alok Atreya

Academic Editor

PLOS Global Public Health

Journal Requirements:

1. Please include a complete copy of PLOS’ questionnaire on inclusivity in global research in your revised manuscript. Our policy for research in this area aims to improve transparency in the reporting of research performed outside of researchers’ own country or community. The policy applies to researchers who have travelled to a different country to conduct research, research with Indigenous populations or their lands, and research on cultural artefacts. The questionnaire can also be requested at the journal’s discretion for any other submissions, even if these conditions are not met.  Please find more information on the policy and a link to download a blank copy of the questionnaire here: https://journals.plos.org/globalpublichealth/s/best-practices-in-research-reporting. Please upload a completed version of your questionnaire as Supporting Information when you resubmit your manuscript.

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3. We noticed that you used "data not shown" in the manuscript. We do not allow these references, as the PLOS data access policy requires that all data be either published with the manuscript or made available in a publicly accessible database. Please amend the supplementary material to include the referenced data or remove the references.

4. We do not publish any copyright or trademark symbols that usually accompany proprietary names, eg  ©, ®, ™  (e.g. next to drug or reagent names). Please remove all instances of trademark/copyright symbols throughout the text, including © on page 11.

Additional Editor Comments (if provided):

Overall, this is a well-written manuscript presenting important data on the disproportionate burden of homicide among males in South Africa. The methods are sound and appropriately described, the results are clearly presented, and the discussion provides good context for interpreting the findings. The authors make a compelling case that more attention needs to be paid to violence prevention among men and boys in South Africa. I have only a few minor suggestions:

Methods:

- The sampling methods and case selection criteria are clearly described. However, it would be helpful to state the final sample size included in the analyses after exclusions.

- Were any steps taken to address missing data? This is not discussed but seems relevant for variables like blood alcohol concentration.

Results:

- The results are comprehensive and informative. The tables effectively summarize key findings.

- It would be interesting to see age-stratified rates for different mechanisms of homicide (e.g. firearm injuries) between males and females. Are the differences most pronounced in certain age groups?

Discussion:

- The discussion contextualizes the results well and makes a strong case for the need to address violence against men and boys.

- When comparing to the previous 2009 national study, it would be helpful to comment on whether the sampling methods were comparable between the two time points.

- Were statistical tests done to assess changes over time? If so, it would be useful to report whether observed differences were statistically significant.

Overall this is a nicely written paper that makes an important contribution to the literature on violence and injuries in South Africa. My suggestions are minor and intended to provide a bit more methodological detail.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Does this manuscript meet PLOS Global Public Health’s publication criteria? Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe methodologically and ethically rigorous research with conclusions that are appropriately drawn based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: No

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available (please refer to the Data Availability Statement at the start of the manuscript PDF file)?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception. The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: No

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS Global Public Health does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: 1. why is data from only 8 out of 9 provinces were collected?

2. briefly discuss about alcohol test. what was teh test, how, when because there are likelihood of error and bias.. since it is mentioned as (1) objective in the introduction section.

Reviewer #2: The authors have tackled a very important public health issue in South Africa. In addition, they have conducted a very well-designed study and have presented the findings excellently. They deserve our congratulations. I do not have any methodological critiques of their paper – only minor comments below:

1. What proportion of homicides were due to multiple mechanisms (blunt and penetrating for example)?

2. There are a few typos on page 5 – “homides” instead of “homicides”; missing word in the second sentence in the Discussion section. Another round of copyedits will suffice.

Congratulations once again.

Reviewer #3: Thank you for submitting this original study focused on understanding the burden of homicide in the South African context. This study retrospectively analyzed data from postmortem investigations, and focused on sex specific differences in rates of homicide. The conclusions of the study focus on the fact that men are significantly more likely to be victims of homicide than females, and the statistical methods focus on this as the main conclusions.

While the data represents a very interesting source of information, the conclusions need to be considerably refocused. The comparison between homicide in men and women while justified in theory by the data, does not really provide any helpful information that should educate future interventions. The focus on gender is a missed opportunity in terms of use of this data, and this paper would benefit from being focused more on the high rates of homicide in men and specific sources of homicide rooted in geography, sociodemographic characteristics other than gender, and a more data-driven conclusion. The authors seem to interject a lot of opinion in the study regarding poverty, inequality, firearm use, and alcohol use, but this is not really discussed in full detail in the study because of the focus on gender.

1. Focus the study on root causes of homicide in men, and remove the focus on comparisons between men and women. An unintended consequence of this study would be to defund initiatives focused on homicide and injury prevention in women and children, so this manuscript needs to be completely rewritten to prevent this sort of downstream policy consequence.

2. The conclusions need to be much more data driven. This could include a focus on geographic differences and associated differences in policy, firearm usage and policy changes over time within each of the regions affected, and other such detailed analyses of the data that can be more helpful from a policy standpoint.

3. The authors must confirm that the data is publicly available based on the guidelines of the PLOS journals.

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6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

Do you want your identity to be public for this peer review? If you choose “no”, your identity will remain anonymous but your review may still be made public.

For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #2: No

Reviewer #3: No

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Attachment

Submitted filename: PGPH-D-23-01105 reviewed.pdf

Attachment

Submitted filename: Reviewer Comments PLOS Global Health South Africa Homicide.docx

PLOS Glob Public Health. doi: 10.1371/journal.pgph.0002595.r003

Decision Letter 1

Alok Atreya

18 Oct 2023

South Africa’s male homicide epidemic hiding in plain sight: exploring sex differences and patterns in homicide risk in a retrospective descriptive study of postmortem investigations

PGPH-D-23-01105R1

Dear Dr Matzopoulos,

We are pleased to inform you that your manuscript 'South Africa’s male homicide epidemic hiding in plain sight: exploring sex differences and patterns in homicide risk in a retrospective descriptive study of postmortem investigations' has been provisionally accepted for publication in PLOS Global Public Health.

Before your manuscript can be formally accepted you will need to complete some formatting changes, which you will receive in a follow up email. A member of our team will be in touch with a set of requests.

Please note that your manuscript will not be scheduled for publication until you have made the required changes, so a swift response is appreciated.

IMPORTANT: The editorial review process is now complete. PLOS will only permit corrections to spelling, formatting or significant scientific errors from this point onwards. Requests for major changes, or any which affect the scientific understanding of your work, will cause delays to the publication date of your manuscript.

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they'll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact globalpubhealth@plos.org.

Thank you again for supporting Open Access publishing; we are looking forward to publishing your work in PLOS Global Public Health.

Best regards,

Alok Atreya

Academic Editor

PLOS Global Public Health

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Reviewer Comments (if any, and for reference):

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

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2. Does this manuscript meet PLOS Global Public Health’s publication criteria? Is the manuscript technically sound, and do the data support the conclusions? The manuscript must describe methodologically and ethically rigorous research with conclusions that are appropriately drawn based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available (please refer to the Data Availability Statement at the start of the manuscript PDF file)?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception. The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS Global Public Health does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: I am satisfied with all the answers except the alcohol concentration. Only the test has been mentioned. It would have made a better impact if it were to include the method of collection and inclusion and exclusion criteria for it because where it can present as an artefact.

Reviewer #2: (No Response)

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7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

Do you want your identity to be public for this peer review? If you choose “no”, your identity will remain anonymous but your review may still be made public.

For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

Reviewer #2: No

**********

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    S1 Table. External cause of homicide categories included in the injury-related mortality survey and corresponding ICD-10 codes, South Africa, 2017.

    (DOCX)

    S1 Text. Inclusivity in global research.

    (DOCX)

    Attachment

    Submitted filename: PGPH-D-23-01105 reviewed.pdf

    Attachment

    Submitted filename: Reviewer Comments PLOS Global Health South Africa Homicide.docx

    Attachment

    Submitted filename: response to reviewers.docx

    Data Availability Statement

    Availability of data used in the study would be subject to permission by the Health Research Ethics Committee and provincial authorities that approved the original study. This is a recently completed study and the dataset will initially be used for capacity development among the emerging researchers on study team. Thereafter access to a de-identified dataset is available upon reasonable request. Requests should be sent to the convenor of the South African Medical Research Council’s Research Ethics Office, Ms Adri Labuschagne (Adri.Labuschagne@mrc.ac.za), for consideration. Guidelines for applications and related materials are available at: https://www.samrc.ac.za/research/rio-research-ethics-office A period of 24 months after publication of the main study results should elapse before requests are made, to allow the authors to publish sub-studies and further analyses.


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