Ameliorative effect of ginsenoside on IBD in dogs. (A) Canine inflammatory bowel disease activity indices (CIBDAIs). (B) Comparison of CRP levels in serum among the three groups. (C) Representative H.E. staining histological sections of the MOD group. (D) Representative H.E. staining histological sections of the GIN group. (E) Representative H.E. staining histological sections of the PRE group. (F) Representative AB staining sections of the MOD group. (G–J) Immunohistochemical staining of Claudin 1, Occludin, ZO-1, E-Cadherin in the MOD group. (K) Representative AB staining sections of the GIN group. (L–O) Immunohistochemical staining of Claudin 1, Occludin, ZO-1, E-Cadherin in the GIN group. (P) Representative AB staining sections of the PRE group. (Q–T) Immunohistochemical staining of Claudin 1, Occludin, ZO-1, E-Cadherin in the PRE group. (U) Comparison of mucus expression in the colon among the three groups. (V) Comparison of Claudin 1 expression in the colon among the three groups. (W) Comparison of Occludin expression in the colon among the three groups. (X) Comparison of ZO-1 expression in the colon among the three groups. (Y) Comparison of E-Cadherin expression in the colon among the three groups. * and ** indicate p < 0.05 and p < 0.01, respectively.