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. 2023 Nov 22;623(7989):1026–1033. doi: 10.1038/s41586-023-06762-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a Individual subtomograms of all the membrane-membrane interfaces were aligned and averaged (left panel). In the middle panel, the coordinates of Env bound to one (purple), two (cyan) and three (green) CD4 molecules are overlaid onto the averaged volumes. The top-down view is shown to the right. b, c Gallery of HIV-1 Env trimers bound to CD4 receptors on biological membranes. Representative images from cryo-tomograms of the HIV-1 Env trimers bound to one CD4 (b) or two and three CD4 (c) molecules at the membrane-membrane interfaces between HIV-1 and MLV-CD4 particles. Scale bar = 20 nm.