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. 2023 Aug 28;146(12):5070–5085. doi: 10.1093/brain/awad249

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Depletion of YFP+ cells from the parenchyma in Δ10 homozygous mice. Comparison of +/Δ10 (A) and Δ10/Δ10 (B) demonstrated widespread depletion of yellow fluorescent protein positive (YFP+) cells in the parenchyma of Δ10/Δ10. Representative images shown. Among remaining YFP+ cells, Δ10/Δ10 had cells with shorter processes and more immature morphology. Inset pictures show the hindbrain, midbrain, splenium of the corpus callosum, and anterior commissure. Δ10/Δ10 = tamoxifen-treated transgenic mice carrying a Pdgfrα-CreERT allele and homozygous Polr3b^fl alleles; +/Δ10 = tamoxifen-treated transgenic mice carrying a Pdgfrα-CreERT allele and heterozygous Polr3b^fl alleles; CTRL = tamoxifen-treated transgenic mice carrying no Pdgfrα-CreERT allele(s); CC1 = clone CC1 of anti-adenomatous polyposis coli (also: Anti-Quaking 7).