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[Preprint]. 2023 Nov 21:2023.11.20.567893. [Version 1] doi: 10.1101/2023.11.20.567893

SmCCNet 2.0: an Upgraded R package for Multi-omics Network Inference

Weixuan Liu, Thao Vu, Iain R Konigsberg, Katherine A Pratte, Yonghua Zhuang, Katerina J Kechris
PMCID: PMC10690212  PMID: 38045372

Abstract

Summary

Sparse multiple canonical correlation network analysis (SmCCNet) is a machine learning technique for integrating omics data along with a variable of interest (e.g., phenotype of complex disease), and reconstructing multiomics networks that are specific to this variable. We present the second-generation SmCCNet (SmCCNet 2.0) that adeptly integrates single or multiple omics data types along with a quantitative or binary phenotype of interest. In addition, this new package offers a streamlined setup process that can be configured manually or automatically, ensuring a flexible and user-friendly experience.

Availability

This package is available in both CRAN: https://cran.r-project.org/web/packages/SmCCNet/index.html and Github: https://github.com/KechrisLab/SmCCNet under the MIT license. The network visualization tool is available in https://smccnet.shinyapps.io/smccnetnetwork/ .

Full Text Availability

The license terms selected by the author(s) for this preprint version do not permit archiving in PMC. The full text is available from the preprint server.


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