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[Preprint]. 2023 Nov 20:arXiv:2311.12143v1. [Version 1]

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FIG. 11 — As mRNA expression decreases, cell cycle dependence shifts to a non-monotonic pattern, with a transient peak around the time of gene replication. Top, smFISH measurement of nascent mRNA from the lac promoter at different expression levels. Bottom, the effect of gene replication on lac transcription as a function of the expression level. The amplitude of transient expression pulse (relative to the expected dosage response) is plotted versus the mRNA copy number per cell. Adapted from (Wang et al., 2019).