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. 2023 Jun 22;108(12):3480–3484. doi: 10.3324/haematol.2022.282591

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Figure 2. — Impact of pinworm exposure on leukemia/lymphoma development in the absence and presence of E6R1. Cumulative survival curves showing combined data from Figure 1 of four independent experiments of mice housed in a pinworm-free (SPF) facility or pinworm-infected facility. Leukemia/lymphoma-free survival for (A) SPF-housed (open symbols) and (B) pinworm-exposed (filled symbols) Cdkn2a^-/- mice (black triangles) and E6R1⁺ Cdkn2a^-/- mice (orange squares). Leukemia/lymphoma-free survival for genotype-matched (C) Cdkn2a^-/- mice and (D) E6R1⁺ Cdkn2a^-/- mice. SPF Cdkn2a^-/- mice (N=76), SPF-housed E6R1⁺ Cdkn2a^-/- mice (N=55), pinworm-exposed Cdkn2a^-/- mice (N=54), and pinworm-exposed E6R1⁺ Cdkn2a^-/- mice (N=44). The logrank (Mantel-Cox) test was applied to the survival curves.