Abstract
The relationship between metallothionein (MT), chronic exposure to cadmium (Cd), and renal function was investigated in 53 men who were occupationally exposed to Cd. The aim was to determine if MT is a potential biological monitor for chronic exposure to Cd which would be useful for preventing Cd nephropathy. In this study MT excretion, serum MT, and serum creatinine concentrations were significantly higher in subjects with abnormal renal function who had been exposed to Cd. MT excretion was also linearly related on an individual basis to protein excretion, beta 2-microglobulin (beta 2-M) excretion, and cumulative time weighted exposure (dose). MT excretion was also a better predictor of dose than either beta 2-M excretion or Cd excretion. The findings suggest that MT is a potential biological monitor for chronic Cd exposure that would be useful for preventing Cd-induced nephropathy. Further studies of non-specific nephropathies and MT are needed to determine if MT is a specific indicator of proximal tubule function secondary to chronic exposure to Cd.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chang C. C., Vander Mallie R. J., Garvey J. S. A radioimmunoassay for human metallothionein. Toxicol Appl Pharmacol. 1980 Aug;55(1):94–102. doi: 10.1016/0041-008x(80)90224-0. [DOI] [PubMed] [Google Scholar]
- Cherian M. G., Goyer R. A., Delaquerriere-Richardson L. Cadmium-metallothionein-induced nephropathy. Toxicol Appl Pharmacol. 1976 Nov;38(2):399–408. doi: 10.1016/0041-008x(76)90146-0. [DOI] [PubMed] [Google Scholar]
- Ellis K. J., Morgan W. D., Zanzi I., Yasumura S., Vartsky D., Cohn S. H. In vivo measurement of critical level of kidney cadmium: dose effect studies in cadmium smelter workers. Am J Ind Med. 1980;1(3-4):339–348. doi: 10.1002/ajim.4700010310. [DOI] [PubMed] [Google Scholar]
- Falck F. Y., Jr, Fine L. J., Smith R. G., McClatchey K. D., Annesley T., England B., Schork A. M. Occupational cadmium exposure and renal status. Am J Ind Med. 1983;4(4):541–549. doi: 10.1002/ajim.4700040408. [DOI] [PubMed] [Google Scholar]
- Gompertz D. Assessment of risk by biological monitoring. Br J Ind Med. 1981 May;38(2):198–201. doi: 10.1136/oem.38.2.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kjellström T., Evrin P. E., Rahnster B. Dose-response analysis of cadmium-induced tubular proteinuria: a study of urinary beta2-microglobulin excretion among workers in a battery factory. Environ Res. 1977 Apr;13(2):303–317. doi: 10.1016/0013-9351(77)90106-2. [DOI] [PubMed] [Google Scholar]
- Mallie R. J., Garvey J. S. Production and study of antibody produced against rat cadmium thionein. Immunochemistry. 1978 Dec;15(12):857–868. doi: 10.1016/0161-5890(78)90119-0. [DOI] [PubMed] [Google Scholar]
- Smith T. J., Anderson R. J., Reading J. C. Chronic cadmium exposures associated with kidney function effects. Am J Ind Med. 1980;1(3-4):319–337. doi: 10.1002/ajim.4700010309. [DOI] [PubMed] [Google Scholar]
- Tohyama C., Shaikh Z. A., Nogawa K., Kobayashi E., Honda R. Elevated urinary excretion of metallothionein due to environmental cadmium exposure. Toxicology. 1981;20(4):289–297. doi: 10.1016/0300-483x(81)90036-6. [DOI] [PubMed] [Google Scholar]
- Vander Mallie R. J., Garvey J. S. Radioimmunoassay of metallothioneins. J Biol Chem. 1979 Sep 10;254(17):8416–8421. [PubMed] [Google Scholar]