Abstract
Bone marrow specimens were obtained from seven workers who had been exposed to the dust of a calcareous sandstone consisting of 56·3% free silica. The pattern of changes was in the form of generalized hyperplasia, and in particular there were very high figures for the myeloid series, reticulum cells, and plasma cells. The eosinophils showed a slight but definite increase but the erythrocytes, megakaryocytes, lymphocytes, and monocytes were within the normal range. These changes were considered to be related to silicosis since other diseases causing stimulation of the bone marrow had been adequately excluded.
The findings correlate with the histopathological changes which are reported to occur in the lungs of silicotic patients; they indicate a high degree of stimulation of the reticulo-endothelial system.
If these changes are considered together with the industrial history and clinical and laboratory data, they may provide a clue to the diagnosis of silicosis and help in the differential diagnosis from other diffuse pulmonary lesions.
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- BARHAD B., VLAD A., DRON F. Le modificazioni elettroforetiche del siero nella silicosi a rapida evoluzione. Med Lav. 1958 Jun-Jul;49(6-7):419–427. [PubMed] [Google Scholar]
- BUSCARINI L., NICROSINI F. [Serum proteins and glycoproteins in pulmonary silicosis]. Med Lav. 1959 May;50:368–378. [PubMed] [Google Scholar]
- CURRAN R. C., ROWSELL E. V. The application of the diffusion-chamber technique to the study of silicosis. J Pathol Bacteriol. 1958 Oct;76(2):561–568. doi: 10.1002/path.1700760225. [DOI] [PubMed] [Google Scholar]
- ENGLEBRECHT F. M., YOGANATHAN M., KING E. J., NAGELSCHMIDT G. Fibrosis and collagen in rats' lungs produced by etched and unetched free silica dusts. AMA Arch Ind Health. 1958 Apr;17(4):287–294. [PubMed] [Google Scholar]
- GHISLANDI E., PERNIS B. Studi chimico-biologici sullo jalino della silicosi. III. Identificazione di una frazione proteica avente le caratteristiche chimiche delle beta-globuline. Med Lav. 1956 Aug-Sep;47(8-9):460–464. [PubMed] [Google Scholar]
- KING E. J., MOHANTY G. P., HARRISON C. V., NAGELSCHMIDT G. Effect of modifications of the surface of quartz on its fibrogenic properties in the lungs of rats. 1. Quartz leached with ringer's solution. 2. Quartz etched with hydrofluoric acid. 3. Quartz coated with coal extract. AMA Arch Ind Hyg Occup Med. 1953 Jun;7(6):455–477. [PubMed] [Google Scholar]
- SAITA G., DI NARO C. Il midollo osseo nella silicosi. Med Lav. 1951 Jun-Jul;42(6-7):201–215. [PubMed] [Google Scholar]
- VIGLIANI E. C., PERNIS B. Immunological factors in the pathogenesis of the hyaline tissue of silicosis. Br J Ind Med. 1958 Jan;15(1):8–14. doi: 10.1136/oem.15.1.8. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VOGLIAZZO U., GHEIS F. [Lysozyme activity in the blood serum of 200 silicotics]. Med Lav. 1961 Apr;52:262–270. [PubMed] [Google Scholar]