Skip to main content
NCBI home page
British Journal of Industrial Medicine logoLink to British Journal of Industrial Medicine
. 1973 Oct;30(4):381–384. doi: 10.1136/oem.30.4.381

Pharmacological prevention of acute ventilatory capacity reduction in flax dust exposure

F Valić 1, Eugenija Žuškin 1
PMCID: PMC1069479  PMID: 4148157

Abstract

Valić, F., and Žuškin, E. (1973).British Journal of Industrial Medicine,30, 381-384. Pharmacological prevention of acute ventilatory capacity reduction in flax dust exposure. The protective effect of the preshift application of a bronchodilator (orciprenaline), an antihistamine drug (diadril), and ascorbic acid on flax-induced acute bronchoconstriction was studied in 13 byssinotic and 7 non-byssinotic female workers exposed to airborne fibres of biologically retted flax. Orciprenaline was applied by inhalation, while diadril and ascorbic acid were given orally. All the three drugs exerted a significant preventive effect, diminishing the acute fall of ventilatory capacity during the shift. The fall in forced expiratory volume (FEV1·0) was reduced by 50% and the fall in maximal flow rate at 50% vital capacity (V̇max 50% VC) by over 65%.

Full text

PDF
381

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOUHUYS A. Prevention of Monday dyspnea in byssinosis: a controlled trial with an antihistamine drug. Clin Pharmacol Ther. 1963 May-Jun;4:311–314. doi: 10.1002/cpt196343311. [DOI] [PubMed] [Google Scholar]
  2. BOUHUYS A., van DUYN, van LENNEP H. Byssinosis in flax workers. Arch Environ Health. 1961 Nov;3:499–509. doi: 10.1080/00039896.1961.10663061. [DOI] [PubMed] [Google Scholar]
  3. Bouhuys A., Van de Woestijne K. P. Respiratory mechanics and dust exposure in byssinosis. J Clin Invest. 1970 Jan;49(1):106–118. doi: 10.1172/JCI106209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dawson W., West G. B. The nature of the antagonism of bronchospasm in the guinea-pig by ascorbic acid. J Pharm Pharmacol. 1965 Sep;17(9):595–596. doi: 10.1111/j.2042-7158.1965.tb07729.x. [DOI] [PubMed] [Google Scholar]
  5. Peters J. M., Mead J., Van Ganse W. F. A simple flow-volume device for measuring ventilatory function in the field. Results on workers exposed to low levels of toluene diisocyanate. Am Rev Respir Dis. 1969 Apr;99(4):617–622. doi: 10.1164/arrd.1969.99.4P1.617. [DOI] [PubMed] [Google Scholar]
  6. Valić F., Zuskin E. Effects of hemp dust exposure on nonsmoking female textile workers. Arch Environ Health. 1971 Nov;23(5):359–364. doi: 10.1080/00039896.1971.10666021. [DOI] [PubMed] [Google Scholar]
  7. Zuskin E., Lewis A. J., Bouhuys A. Inhibition of histamine-induced airway constriction by ascorbic acid. J Allergy Clin Immunol. 1973 Apr;51(4):218–226. doi: 10.1016/0091-6749(73)90141-3. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Industrial Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES