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. 2023 Nov 7;26(12):108409. doi: 10.1016/j.isci.2023.108409

Figure 4.

Figure 4

B1KO mothers have lower expression of leptin receptors in the placenta

Effect of the lack of maternal B1R on serum and placental leptin levels and the gene expression of their receptors in the placenta: serum (A) and placental (B) leptin concentration; isoform a (C) and isoform b (D) of Lepr gene expression. Maternal B1R deficiency reduces leptin receptor expression in heterozygous placenta (isoform a: p = 0.005; isoform b: p = 0.032) with no changes in serum and placental leptin levels. ∗p < 0.05, ∗∗p < 0.01. Data were compared by Mann-Whitney (A) and unpaired t test (B, C, and D) at GraphPad Prism 7. Values expressed as mean ± SD of 4–10 mice per group for serum and placental leptin, or 8–10 placentas per group (2 placentas per dam). Lepr – leptin receptor gene. Blue = WT dam; Red = B1KO dam. See also Figures S3 and S4).