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. 2023 Nov 24;12(23):2701. doi: 10.3390/cells12232701

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Integral membrane proteins at TJs and their interaction with scaffolding proteins. Tight junctions contain a number of membrane proteins including Crumbs3 (CRB3), claudins, TJ-associated marvel proteins (Occludin, MarvelD3, Tricellulin), and members of the immunoglobulin superfamily (JAMs, CAR, ESAM, Angulins). All membrane proteins at the TJ directly interact with one or several scaffolding proteins (depicted in grey color). Some scaffolding proteins interact with several integral membrane proteins, as well as with other scaffolding proteins. For example, MUPP1 can interact with JAM-A, CAR, and claudins, as well as with PALS-1, PAR-6, and ZO-3 (indicated by arrows). Tricellulin and angulins are specifically localized at tricellular TJs.