Correction to: Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation

Correction to: Diabetologia

https://doi.org/10.1007/s00125-022-05729-y

Unfortunately, in the BrdU staining of alpha-TC1.9 cells shown in Fig. 7e, the representative image used in the siRNA-Ide panel was a duplication of the image used for the control panel. The authors assert that this mistake had no impact on the data analysis, interpretation or conclusions drawn. Figure 7e in the original article has been corrected.

Fig. 7.

Deletion of IDE triggers alpha cell proliferation. (a) Representative images of Ki67 (green) and glucagon (red) staining in A-IDE-KO and control mouse pancreases. Scale bar, 40 μm. Arrows point to proliferative/Ki67-positive cells. (b) Quantification of alpha cell proliferation by Ki67/glucagon cells per total number of glucagon cells (n = 9). (c, d) IDE-knockdown in alpha-TC1.9 cells using siRNA-Ide or siRNA-CTL (scrambled control), showing a ~40% decrease in IDE expression (n = 3). (e) Representative images of BrdU staining in IDE-deficient and control alpha-TC1.9 cells. Scale bar, 100 μm. (f) Quantification of proliferation by detection of BrdU-positive cells (n = 9). Data are presented as means ± SEM. *p < 0.05 and **p < 0.01 vs control mouse or vs siRNA-CTL treatment