Table 1.
Dose-escalation schedule for bevacizumab/temsirolimus and valproic acid.
| Dose level | Dose and schedule (28-day cycle) | ||
|---|---|---|---|
| Temsirolimus* | Bevacizumab | Valproic acid | |
| Level -1 | 5 mg days 1, 8, 15, and 22 | 2.5 mg/kg day 1 and 15 | 5 mg/kg rounded to nearest 250 mg daily on days 1-7 and 15-21 |
| Level 0 | 5 mg days 1, 8, 15, and 22 | 5 mg/kg day 1 and 15 | 5 mg/kg rounded to nearest 250 mg daily on days 1-7 and 15-21 |
| Level 1 | 5 mg days 1, 8, 15, and 22 | 10 mg/kg day 1 and 15 | 5 mg/kg rounded to nearest 250 mg daily on days 1-7 and 15-21 |
| Level 2 | 12.5 mg days 1, 8, 15, and 22 | 2.5 mg/kg day 1 and 15 | 5 mg/kg rounded to nearest 250mg daily on days 1-7 and 15-21 |
| Level 3 | 12.5 mg days 1, 8, 15, and 22 | 7.5 mg/kg day 1 and 15 | 10 mg/kg rounded to nearest 250 mg daily on days 1-7 and 15-21 |
| Level 4 | 12.5 mg days 1, 8, 15, and 22 | 10 mg/kg day 1 and 15 | 10 mg/kg rounded to nearest 250 mg daily on days 1-7 and 15-21 |
| Level 5 | 20 mg days 1, 8, 15, and 22 | 2.5 mg/kg day 1 and 15 | 5 mg/kg rounded to nearest 250 mg daily on days 1-7 and 15-21 |
| Level 6 | 20 mg days 1, 8, 15, and 22 | 7.5 mg/kg day 1 and 15 | 10 mg/kg rounded to nearest 250 mg daily on days 1-7 and 15-21 |
| Level 7 | 20 mg days 1, 8, 15, and 22 | 10 mg/kg day 1 and 15 | 10 mg/kg rounded to nearest 250 mg daily on days 1-7 and 15-21 |
| Level 8 | 25 mg days 1, 8, 15, and 22 | 2.5 mg/kg day 1 and 15 | 5 mg/kg rounded to nearest 250 mg daily on days 1-7 and 15-21 |
| Level 9 | 25 mg days 1, 8, 15, and 22 | 5 mg/kg day 1 and 15 | 5 mg/kg rounded to nearest 250 mg daily on days 1-7 and 15-21 |
| Level 10 | 25 mg days 1, 8, 15, and 22 | 10 mg/kg day 1 and 15 | 10 mg/kg rounded to nearest 250 mg daily on days 1-7 and 15-21 |