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. Author manuscript; available in PMC: 2024 May 15.
Published in final edited form as: J Immunol. 2023 Nov 15;211(10):1450–1458. doi: 10.4049/jimmunol.2200682

Figure 1. T cell receptor signaling pathway members and frequency of SNVs and CNVs in AITL, ATL, CTCL, and PTCL-NOS.

Figure 1.

T cell signaling pathway members discussed previously are shown. Proximal PTKs activate scaffolding proteins (e.g., LAT, GADS, and SLP-76) that recruit and activate downstream enzymes such as PLCγ1, VAV1, and RHOA. Signals converge at hubs such as the CARD11/BCL10/MALT1 (CBM) complex and activate downstream nuclear factor of activated T-cells (NFAT), activator protein-1 (AP-1), nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB), and mammalian target of rapamycin (mTOR) signaling pathways. A red border signifies genes with oncogenic mutations described above. A blue border denotes a tumor suppressor role in TCLs. The SNV and CNV frequencies in a cohort of AITL, ATL, CTCL, and PTCL-NOS (including Tfh-PTCL) samples as previously described are shown(28, 29, 40, 60, 62, 63, 95, 129). Red: AITL; Yellow: ATL; Blue: CTCL; Purple: PTCL-NOS. The SNV frequency is displayed for AITL, ATL, CTCL, and PTCL-NOS in the first row in darker color. The CNV frequency is displayed for ATL, CTCL, and PTCL-NOS in the second row in lighter color.