Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1955 Jun;34(6):867–874. doi: 10.1172/JCI103142

Cardiovascular and Renal Responses to the Combination of Hexamethonium and 1-Hydrazinophthalazine (Apresoline®) in Hypertensive Subjects1

David H Stein a, Hans H Hecht a
PMCID: PMC1072617  PMID: 14381516

Full text

PDF
867

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. FREIS E. D., FINNERTY F. A., Jr Suppression of vasomotor reflexes in man following L-hydrazinophthalozine (C-5968). Proc Soc Exp Biol Med. 1950 Oct;75(1):23–24. doi: 10.3181/00379727-75-18085. [DOI] [PubMed] [Google Scholar]
  2. GRIMSON K. S., ORGAIN E. S., ROWE C. R., Jr, SIEBER H. A. Caution with regard to use of hexamethonium and "apresoline". J Am Med Assoc. 1952 May 17;149(3):215–220. doi: 10.1001/jama.1952.02930200001001. [DOI] [PubMed] [Google Scholar]
  3. JOHNSON R. L., FREIS E. D., SCHNAPER H. W. Clinical evaluation of 1-hydrazinophthalazine (C-5968) in hypertension, with special reference to alternating treatment with hexamethonium. Circulation. 1952 Jun;5(6):833–841. doi: 10.1161/01.cir.5.6.833. [DOI] [PubMed] [Google Scholar]
  4. MILLS L. C., MOYER J. H. The acute effects of hexamethonium on renal hemodynamics in normotensive and hypertensive human subjects. Am J Med Sci. 1953 Jul;226(1):1–15. doi: 10.1097/00000441-195307000-00001. [DOI] [PubMed] [Google Scholar]
  5. MORROW J. D., SCHROEDER H. A., PERRY H. M., Jr Studies on the control of hypertension by hyphex. II. Toxic reactions and side effects. Circulation. 1953 Dec;8(6):829–839. doi: 10.1161/01.cir.8.6.829. [DOI] [PubMed] [Google Scholar]
  6. MOYER J. H., HANDLEY C. A., HUGGINS R. A. Some pharmacodynamic effects of 1-hydrazinophthalazine (C-5968) with particular reference to renal function and cardiovascular response. J Pharmacol Exp Ther. 1951 Dec;103(4):368–376. [PubMed] [Google Scholar]
  7. MOYER J. H., HUGGINS R. A., HANDLEY C. A., MILLS L. C. Effect of hexamethonium chloride on cardiovascular and renal hemodynamics and on electrolyte excretion. J Pharmacol Exp Ther. 1952 Oct;106(2):157–165. [PubMed] [Google Scholar]
  8. MOYER J. H. Hydrallazine (apresoline) hydrochloride; pharmacological observations and clinical results in the therapy of hypertension. AMA Arch Intern Med. 1953 Apr;91(4):419–439. doi: 10.1001/archinte.1953.00240160005002. [DOI] [PubMed] [Google Scholar]
  9. MOYER J. H., MILLS L. C. Hexamethonium-its effect on glomerular filtration rate, maximal tubular function and renal excretion of electrolytes. J Clin Invest. 1953 Feb;32(2):172–184. doi: 10.1172/JCI102725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. REUBI F. C. Renal hyperemia induced in man by a new phthalazine derivative. Proc Soc Exp Biol Med. 1950 Jan;73(1):102–102. doi: 10.3181/00379727-73-17591. [DOI] [PubMed] [Google Scholar]
  11. SCHROEDER H. A. Control of hypertension by hexamethonium and 1-hydrazinophthalazine; preliminary observations. AMA Arch Intern Med. 1952 Apr;89(4):523–540. doi: 10.1001/archinte.1952.00240040002001. [DOI] [PubMed] [Google Scholar]
  12. SCHROEDER H. A., MORROW J. D., PERRY H. M., Jr Studies on the control of hypertension by hyphex. I. Effects on blood pressure. Circulation. 1953 Nov;8(5):672–680. doi: 10.1161/01.cir.8.5.672. [DOI] [PubMed] [Google Scholar]
  13. WALKER H. A., WILSON S., ATKINS E. C., GARRETT H. E., RICHARDSON A. P. The effect of 1-hydrazinophthalazine (C-5968) and related compounds on the cardiovascular system of dogs. J Pharmacol Exp Ther. 1951 Apr;101(4):368–378. [PubMed] [Google Scholar]
  14. WILKINSON E. L., BACKMAN H., HECHT H. H. Cardiovascular and renal adjustments to a hypotensive agent (l'hydrazinophthalazine: Ciba BA-5968: apresoline). J Clin Invest. 1952 Oct;31(10):872–879. doi: 10.1172/JCI102674. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES