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. 1957 Dec;36(12):1647–1655. doi: 10.1172/JCI103565

Toxicity and Blood Ammonia Rise Resulting from Intravenous Amino Acid Administration in Man: The Protective Effect of l-Arginine

John L Fahey 1
PMCID: PMC1072776  PMID: 13491695

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABELY P., LAB P. Suite aux enseignements séméiologiques et doctrinaux découlant de l'usage des neuroleptiques. Ann Med Psychol (Paris) 1957 Dec;115(5):957–962. [PubMed] [Google Scholar]
  2. BEAVERS W. R., COVINO B. G. Immersion hypothermia: effect of glycine. Proc Soc Exp Biol Med. 1956 Jun;92(2):319–322. doi: 10.3181/00379727-92-22464. [DOI] [PubMed] [Google Scholar]
  3. BIRNBAUM S. M., DU RUISSEAU J. P., GREENSTEIN J. P., WINITZ M. Studies on the metabolism of amino acids and related compounds in vivo. IV. Blood ammonia and urea levels following intraperitoneal administration of amino acids and ammonium acetate, and the effect of arginine thereon. Arch Biochem Biophys. 1956 Oct;64(2):355–367. doi: 10.1016/0003-9861(56)90279-x. [DOI] [PubMed] [Google Scholar]
  4. DOOLAN P. D., HARPER H. A., HUTCHIN M. E., ALPEN E. L. The renal tubular response to amino acid loading. J Clin Invest. 1956 Aug;35(8):888–896. doi: 10.1172/JCI103341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GREENSTEIN J. P. The resolution of racemic alpha-amino acids. Adv Protein Chem. 1954;9:121–202. doi: 10.1016/s0065-3233(08)60206-5. [DOI] [PubMed] [Google Scholar]
  6. GREENSTEIN J. P. The resolution of racemic alpha-amino acids. Adv Protein Chem. 1954;9:121–202. doi: 10.1016/s0065-3233(08)60206-5. [DOI] [PubMed] [Google Scholar]
  7. GREENSTEIN J. P., WINITZ M., GULLINO P., BIRNBAUM S. M. The prevention of ammonia toxicity by L-arginine and related compounds. Arch Biochem Biophys. 1955 Nov;59(1):302–303. doi: 10.1016/0003-9861(55)90490-2. [DOI] [PubMed] [Google Scholar]
  8. GULLINO P., WINITZ M., BIRNBAUM S. M., CORNFIELD J., OTEY M. C., GREENSTEIN J. P. Studies on the metabolism of amino acids and related compounds in vivo. I. Toxicity of essential amino acids, individually and in mixtures, and the protective effect of L-arginine. Arch Biochem Biophys. 1956 Oct;64(2):319–332. doi: 10.1016/0003-9861(56)90276-4. [DOI] [PubMed] [Google Scholar]
  9. GULLINO P., WINITZ M., BIRNBAUM S. M., OTEY M. C., CORNFIELD J., GREENSTEIN J. P. The toxicity of essential amino acid mixtures with special reference to the protective effect of L-arginine. Arch Biochem Biophys. 1955 Sep;58(1):255–257. doi: 10.1016/0003-9861(55)90119-3. [DOI] [PubMed] [Google Scholar]
  10. HARPER H. A., NAJARIAN J. S. Comparative effect of arginine and monosodium glutamate on blood ammonia. Proc Soc Exp Biol Med. 1956 Jul;92(3):560–563. doi: 10.3181/00379727-92-22544. [DOI] [PubMed] [Google Scholar]
  11. HARPER H. A., NAJARIAN J. S., SILEN W. Effect of intravenously administered amino acids on blood ammonia. Proc Soc Exp Biol Med. 1956 Jul;92(3):558–560. doi: 10.3181/00379727-92-22543. [DOI] [PubMed] [Google Scholar]
  12. KAMIN H., HANDLER P. The metabolism of parenterally administered amino acids. II. Urea synthesis. J Biol Chem. 1951 Jan;188(1):193–205. [PubMed] [Google Scholar]
  13. Lyttle J. D., Goettsch E., Greeley D. M., Grim W. M., Dunbar P. AMINO ACID STUDIES. II. PLASMA AMINO ACID RETENTION, AS EVIDENCE OF IMPAIRED LIVER FUNCTION. INVESTIGATIONS IN CHILDREN WITH NEPHROSIS AND LIVER DISEASE. J Clin Invest. 1943 Mar;22(2):169–181. doi: 10.1172/JCI101380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. SEEGMILLER J. E., SCHWARTZ R., DAVIDSON C. S. The plasma ammonia and glutamine content in patients with hepatic coma. J Clin Invest. 1954 Jul;33(7):984–988. doi: 10.1172/JCI102976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SELIGSON D., HIRAHARA K. The measurement of ammonia in whole blood, erythrocytes, and plasma. J Lab Clin Med. 1957 Jun;49(6):962–974. [PubMed] [Google Scholar]
  16. SELIGSON D., SELIGSON H. A microdiffusion method for the determination of nitrogen liberated as ammonia. J Lab Clin Med. 1951 Aug;38(2):324–330. [PubMed] [Google Scholar]

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