Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1994 May;57(5):655–657. doi: 10.1136/jnnp.57.5.655

Congenital protein C deficiency and superior sagittal sinus thrombosis causing isolated intracranial hypertension.

C Confavreux 1, P Brunet 1, P Petiot 1, M Berruyer 1, M Trillet 1, G Aimard 1
PMCID: PMC1072943  PMID: 8201352

Abstract

The first case of a superior sagittal sinus thrombosis causing isolated intracranial hypertension as a result of congenital protein C deficiency is reported. Such a possibility must not be overlooked. Anticoagulation is recommended as a treatment for cerebral venous thrombosis. In the case of congenital protein C deficiency, vitamin K antagonists must be started cautiously due to the risk of skin necrosis.

Full text

PDF
655

Images in this article

655Image
on p.655

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allaart C. F., Poort S. R., Rosendaal F. R., Reitsma P. H., Bertina R. M., Briët E. Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect. Lancet. 1993 Jan 16;341(8838):134–138. doi: 10.1016/0140-6736(93)90003-y. [DOI] [PubMed] [Google Scholar]
  2. Barbui T., Finazzi G., Mussoni L., Riganti M., Donati M. B., Colucci M., Collen D. Hereditary dysfunctional protein C (protein C Bergamo) and thrombosis. Lancet. 1984 Oct 6;2(8406):819–819. doi: 10.1016/s0140-6736(84)90750-5. [DOI] [PubMed] [Google Scholar]
  3. Bhowmick B. K. Benign intracranial hypertension after antibiotic therapy. Br Med J. 1972 Jul 1;3(5817):30–30. doi: 10.1136/bmj.3.5817.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bousser M. G., Chiras J., Bories J., Castaigne P. Cerebral venous thrombosis--a review of 38 cases. Stroke. 1985 Mar-Apr;16(2):199–213. doi: 10.1161/01.str.16.2.199. [DOI] [PubMed] [Google Scholar]
  5. Bovill E. G., Bauer K. A., Dickerman J. D., Callas P., West B. The clinical spectrum of heterozygous protein C deficiency in a large New England kindred. Blood. 1989 Feb 15;73(3):712–717. [PubMed] [Google Scholar]
  6. Broekmans A. W., Veltkamp J. J., Bertina R. M. Congenital protein C deficiency and venous thromboembolism. A study of three Dutch families. N Engl J Med. 1983 Aug 11;309(6):340–344. doi: 10.1056/NEJM198308113090604. [DOI] [PubMed] [Google Scholar]
  7. Camerlingo M., Finazzi G., Casto L., Laffranchi C., Barbui T., Mamoli A. Inherited protein C deficiency and nonhemorrhagic arterial stroke in young adults. Neurology. 1991 Sep;41(9):1371–1373. doi: 10.1212/wnl.41.9.1371. [DOI] [PubMed] [Google Scholar]
  8. Clouse L. H., Comp P. C. The regulation of hemostasis: the protein C system. N Engl J Med. 1986 May 15;314(20):1298–1304. doi: 10.1056/NEJM198605153142006. [DOI] [PubMed] [Google Scholar]
  9. Giuseffi V., Wall M., Siegel P. Z., Rojas P. B. Symptoms and disease associations in idiopathic intracranial hypertension (pseudotumor cerebri): a case-control study. Neurology. 1991 Feb;41(2 ):239–244. doi: 10.1212/wnl.41.2_part_1.239. [DOI] [PubMed] [Google Scholar]
  10. Heijboer H., Brandjes D. P., Büller H. R., Sturk A., ten Cate J. W. Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis. N Engl J Med. 1990 Nov 29;323(22):1512–1516. doi: 10.1056/NEJM199011293232202. [DOI] [PubMed] [Google Scholar]
  11. Johnston I., Hawke S., Halmagyi M., Teo C. The pseudotumor syndrome. Disorders of cerebrospinal fluid circulation causing intracranial hypertension without ventriculomegaly. Arch Neurol. 1991 Jul;48(7):740–747. doi: 10.1001/archneur.1991.00530190088020. [DOI] [PubMed] [Google Scholar]
  12. Koch-Weser J., Gilmore E. B. Benign intracranial hypertension in an adult after tetracycline therapy. JAMA. 1967 Apr 24;200(4):345–347. [PubMed] [Google Scholar]
  13. Loizou S., McCrea J. D., Rudge A. C., Reynolds R., Boyle C. C., Harris E. N. Measurement of anti-cardiolipin antibodies by an enzyme-linked immunosorbent assay (ELISA): standardization and quantitation of results. Clin Exp Immunol. 1985 Dec;62(3):738–745. [PMC free article] [PubMed] [Google Scholar]
  14. Lubetzki C., Sanson M., Cohen D., Schaison-Cusin M., Lhermitte F., Lyon-Caen O. Hypertension intracrânienne bénigne et minocycline. Rev Neurol (Paris) 1988;144(3):218–220. [PubMed] [Google Scholar]
  15. Miletich J., Sherman L., Broze G., Jr Absence of thrombosis in subjects with heterozygous protein C deficiency. N Engl J Med. 1987 Oct 15;317(16):991–996. doi: 10.1056/NEJM198710153171604. [DOI] [PubMed] [Google Scholar]
  16. Monaco F., Agnetti V., Mutani R. Benign intracranial hypertension after minocycline therapy. Eur Neurol. 1978;17(1):48–49. doi: 10.1159/000114921. [DOI] [PubMed] [Google Scholar]
  17. Roos K. L., Pascuzzi R. M., Kuharik M. A., Shapiro A. D., Manco-Johnson M. J. Postpartum intracranial venous thrombosis associated with dysfunctional protein C and deficiency of protein S. Obstet Gynecol. 1990 Sep;76(3 Pt 2):492–494. [PubMed] [Google Scholar]
  18. Tarras S., Gadia C., Meister L., Roldan E., Gregorios J. B. Homozygous protein C deficiency in a newborn. Clinicopathologic correlation. Arch Neurol. 1988 Feb;45(2):214–216. doi: 10.1001/archneur.1988.00520260102029. [DOI] [PubMed] [Google Scholar]
  19. Wintzen A. R., Broekmans A. W., Bertina R. M., Briët E., Briët P. E., Zecha A., Vielvoye G. J., Bots G. T. Cerebral haemorrhagic infarction in young patients with hereditary protein C deficiency: evidence for "spontaneous" cerebral venous thrombosis. Br Med J (Clin Res Ed) 1985 Feb 2;290(6465):350–352. doi: 10.1136/bmj.290.6465.350. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES