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. 2023 Dec 18;11:e16679. doi: 10.7717/peerj.16679

Figure 3. Activation of the PI3K/AKT pathway can alleviate the repressive effect of LINC00969 overexpression on MCF-7 cells.

Figure 3

(A) PI3K, t-AKT, and p-AKT protein expressions in MCF-7 cells transfected with ov-LINC00969 or ov-NC plasmids detected by western blot. (B) PI3K, t-AKT with p-AKT protein expression in MCF-7 cells with LINC00969 overexpression treated with IGF-1 detected by western blot. (C) Proliferation of MCF-7 cells accompanying LINC00969 overexpression after treatment with IGF-1 analyzed by the CCK-8 assay. Migration (D) and invasion (E) of MCF-7 cells overexpressing LINC00969 after treatment with IGF-1 analyzed by the Transwell assay (magnification, 100×) (***P < 0.001).