Abstract
Four families each with two patients with autoimmune myasthenia gravis or related conditions are reported. All clinical forms of myasthenia gravis were represented and different disease types were found within the same family. Either one or two generations could be affected and no association with a single HLA haplotype was found. The frequency of familial autoimmune myasthenia gravis is very low and the genetic factors involved seem to be different from MHC genes.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bell J. I., Steinman L., Toyka K., McDevitt H. O. HLA-DQ restriction fragment length polymorphisms in myasthenia gravis. Ann N Y Acad Sci. 1987;505:382–387. doi: 10.1111/j.1749-6632.1987.tb51308.x. [DOI] [PubMed] [Google Scholar]
- Bergoffen J., Zmijewski C. M., Fischbeck K. H. Familial autoimmune myasthenia gravis. Neurology. 1994 Mar;44(3 Pt 1):551–554. doi: 10.1212/wnl.44.3_part_1.551. [DOI] [PubMed] [Google Scholar]
- Christadoss P. Immunogenetics of experimental autoimmune myasthenia gravis. Crit Rev Immunol. 1989;9(4):247–278. [PubMed] [Google Scholar]
- Goulon M., Tournilhac M., Nouailhat F. Myasthénie familiale auto-immune deux soeurs suivies pendant plus de 30 ans. Rev Neurol (Paris) 1994;150(4):299–301. [PubMed] [Google Scholar]
- Horn G. T., Bugawan T. L., Long C. M., Erlich H. A. Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6012–6016. doi: 10.1073/pnas.85.16.6012. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kerzin-Storrar L., Metcalfe R. A., Dyer P. A., Kowalska G., Ferguson I., Harris R. Genetic factors in myasthenia gravis: a family study. Neurology. 1988 Jan;38(1):38–42. doi: 10.1212/wnl.38.1.38. [DOI] [PubMed] [Google Scholar]
- Monden Y., Uyama T., Nakahara K., Fujii Y., Hashimoto J., Ohno K., Masaoka A., Kawashima Y. Clinical characteristics and prognosis of myasthenia gravis with other autoimmune diseases. Ann Thorac Surg. 1986 Feb;41(2):189–192. doi: 10.1016/s0003-4975(10)62667-7. [DOI] [PubMed] [Google Scholar]
- Namba T., Brunner N. G., Brown S. B., Muguruma M., Grob D. Familial myasthenia gravis. Report of 27 patients in 12 families and review of 164 patients in 73 families. Arch Neurol. 1971 Jul;25(1):49–60. doi: 10.1001/archneur.1971.00490010059009. [DOI] [PubMed] [Google Scholar]
- Newsom-Davis J., Willcox N., Schluep M., Harcourt G., Vincent A., Mossman S., Wray D., Burges J. Immunological heterogeneity and cellular mechanisms in myasthenia gravis. Ann N Y Acad Sci. 1987;505:12–26. doi: 10.1111/j.1749-6632.1987.tb51279.x. [DOI] [PubMed] [Google Scholar]
- Pascuzzi R. M., Sermas A., Phillips L. H., 2nd, Johns T. R. Familial autoimmune myasthenia gravis and thymoma: occurrence in two brothers. Neurology. 1986 Mar;36(3):423–427. doi: 10.1212/wnl.36.3.423. [DOI] [PubMed] [Google Scholar]
- Provenzano C., Arancio O., Evoli A., Rocca B., Bartoccioni E., de Grandis D., Tonali P. Familial autoimmune myasthenia gravis with different pathogenetic antibodies. J Neurol Neurosurg Psychiatry. 1988 Sep;51(9):1228–1230. doi: 10.1136/jnnp.51.9.1228. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Salazar M., Yunis J. J., Delgado M. B., Bing D., Yunis E. J. HLA-DQB1 allele typing by a new PCR-RFLP method: correlation with a PCR-SSO method. Tissue Antigens. 1992 Sep;40(3):116–123. doi: 10.1111/j.1399-0039.1992.tb02102.x. [DOI] [PubMed] [Google Scholar]
- Willcox N. Myasthenia gravis. Curr Opin Immunol. 1993 Dec;5(6):910–917. doi: 10.1016/0952-7915(93)90105-2. [DOI] [PubMed] [Google Scholar]