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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1995 Jun;58(6):742–744. doi: 10.1136/jnnp.58.6.742

Motor neuron disease (amyotrophic lateral sclerosis) arising from longstanding primary lateral sclerosis.

R P Bruyn 1, J H Koelman 1, D Troost 1, J M de Jong 1
PMCID: PMC1073559  PMID: 7608680

Abstract

Three men were initially diagnosed as having primary lateral sclerosis (PLS), but eventually developed amyotrophic lateral sclerosis (ALS) after 7.5, 9, and at least 27 years. Non-familial ALS and PLS might be different manifestations of a single disease or constitute completely distinct entities. The clinical diagnosis of PLS predicts a median survival that is four to five times longer than in ALS.

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Selected References

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