Skip to main content
NCBI home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1995 Jul;59(1):71–76. doi: 10.1136/jnnp.59.1.71

Multiple sclerosis in the north Cambridgeshire districts of East Anglia.

N Robertson 1, J Deans 1, M Fraser 1, D A Compston 1
PMCID: PMC1073604  PMID: 7608713

Abstract

The Cambridgeshire multiple sclerosis register was established in 1989 and initially reported a prevalence of 130/10(5) population for south and east Cambridgeshire (south Cambs). This survey has now been extended to the northern county districts where there were 449 patients with multiple sclerosis in population of 378,959 on 1 July 1993 (118/10(5); 95% confidence interval (95% CI) 108-130). Four hundred and four had either definite or probable disease (107/10(5); 95% CI: 98-118). This matches the highest figures in the series of seven epidemiological surveys carried out in southern England over the past decade. Comparison with these and other studies indicates that no latitudinal gradient of disease is found in southern England despite spanning four degrees of latitude.

Full text

PDF
71

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Confavreux C., Compston D. A., Hommes O. R., McDonald W. I., Thompson A. J. EDMUS, a European database for multiple sclerosis. J Neurol Neurosurg Psychiatry. 1992 Aug;55(8):671–676. doi: 10.1136/jnnp.55.8.671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cook S. D., Cromarty J. I., Tapp W., Poskanzer D., Walker J. D., Dowling P. C. Declining incidence of multiple sclerosis in the Orkney Islands. Neurology. 1985 Apr;35(4):545–551. doi: 10.1212/wnl.35.4.545. [DOI] [PubMed] [Google Scholar]
  3. Crawford P. M., West C. R., Chadwick D. W., Shaw M. D. Arteriovenous malformations of the brain: natural history in unoperated patients. J Neurol Neurosurg Psychiatry. 1986 Jan;49(1):1–10. doi: 10.1136/jnnp.49.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dean G. Annual incidence, prevalence, and mortality of multiple sclerosis in white South-African-born and in white immigrants to South Africa. Br Med J. 1967 Jun 17;2(5554):724–730. doi: 10.1136/bmj.2.5554.724. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Downie A. W., Phadke J. G. The chief scientist reports ... multiple sclerosis in North East Scotland. Health Bull (Edinb) 1984 May;42(3):151–156. [PubMed] [Google Scholar]
  6. Elian M., Dean G. Multiple sclerosis among the United Kingdom-born children of immigrants from the West Indies. J Neurol Neurosurg Psychiatry. 1987 Mar;50(3):327–332. doi: 10.1136/jnnp.50.3.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Elian M., Nightingale S., Dean G. Multiple sclerosis among United Kingdom-born children of immigrants from the Indian subcontinent, Africa and the West Indies. J Neurol Neurosurg Psychiatry. 1990 Oct;53(10):906–911. doi: 10.1136/jnnp.53.10.906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Huttunen J., Hömberg V. EMG responses in leg muscles to postural perturbations in Huntington's disease. J Neurol Neurosurg Psychiatry. 1990 Jan;53(1):55–62. doi: 10.1136/jnnp.53.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kurtzke J. F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983 Nov;33(11):1444–1452. doi: 10.1212/wnl.33.11.1444. [DOI] [PubMed] [Google Scholar]
  10. Lockyer M. J. Prevalence of multiple sclerosis in five rural Suffolk practices. BMJ. 1991 Aug 10;303(6798):347–348. doi: 10.1136/bmj.303.6798.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mumford C. J., Fraser M. B., Wood N. W., Compston D. A. Multiple sclerosis in the Cambridge health district of east Anglia. J Neurol Neurosurg Psychiatry. 1992 Oct;55(10):877–882. doi: 10.1136/jnnp.55.10.877. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Patchell R. A., White C. L., 3rd, Clark A. W., Beschorner W. E., Santos G. W. Neurologic complications of bone marrow transplantation. Neurology. 1985 Mar;35(3):300–306. doi: 10.1212/wnl.35.3.300. [DOI] [PubMed] [Google Scholar]
  13. Phadke J. G., Downie A. W. Epidemiology of multiple sclerosis in the north-east (Grampian region) of Scotland--an update. J Epidemiol Community Health. 1987 Mar;41(1):5–13. doi: 10.1136/jech.41.1.5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Poser C. M., Paty D. W., Scheinberg L., McDonald W. I., Davis F. A., Ebers G. C., Johnson K. P., Sibley W. A., Silberberg D. H., Tourtellotte W. W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. doi: 10.1002/ana.410130302. [DOI] [PubMed] [Google Scholar]
  15. Poskanzer D. C., Prenney L. B., Sheridan J. L., Kondy J. Y. Multiple sclerosis in the Orkney and Shetland Islands. I: Epidemiology, clinical factors, and methodology. J Epidemiol Community Health. 1980 Dec;34(4):229–239. doi: 10.1136/jech.34.4.229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rice-Oxley M., Williams E. S., Rees J. E. A prevalence survey of multiple sclerosis in Sussex. J Neurol Neurosurg Psychiatry. 1995 Jan;58(1):27–30. doi: 10.1136/jnnp.58.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Robertson N., Compston A. Surveying multiple sclerosis in the United Kingdom. J Neurol Neurosurg Psychiatry. 1995 Jan;58(1):2–6. doi: 10.1136/jnnp.58.1.2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Sharpe G., Price S. E., Last A., Thompson R. J. Multiple sclerosis in island populations: prevalence in the Bailiwicks of Guernsey and Jersey. J Neurol Neurosurg Psychiatry. 1995 Jan;58(1):22–26. doi: 10.1136/jnnp.58.1.22. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Shepherd D. I., Downie A. W. A further prevalence study of multiple sclerosis in north-east Scotland. J Neurol Neurosurg Psychiatry. 1980 Apr;43(4):310–315. doi: 10.1136/jnnp.43.4.310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Shepherd D. I., Downie A. W. Prevalence of multiple sclerosis in north-east Scotland. Br Med J. 1978 Jul 29;2(6133):314–316. doi: 10.1136/bmj.2.6133.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Skegg D. C., Corwin P. A., Craven R. S., Malloch J. A., Pollock M. Occurrence of multiple sclerosis in the north and south of New Zealand. J Neurol Neurosurg Psychiatry. 1987 Feb;50(2):134–139. doi: 10.1136/jnnp.50.2.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Swingler R. J., Compston D. A. The prevalence of multiple sclerosis in south east Wales. J Neurol Neurosurg Psychiatry. 1988 Dec;51(12):1520–1524. doi: 10.1136/jnnp.51.12.1520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Williams E. S., McKeran R. O. Prevalence of multiple sclerosis in a south London borough. Br Med J (Clin Res Ed) 1986 Jul 26;293(6541):237–239. doi: 10.1136/bmj.293.6541.237. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES