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. 2023 Dec 14;12(12):1452. doi: 10.3390/pathogens12121452

Figure 5.

Figure 5

A sex difference in anti-MmuPV1 E4 IgG and isotypes was found. Anti-MmuPV1 E4 IgG antibodies in B6, CCR2ko, and Stat1ko mice post-infection. Significantly higher levels of antibodies against E4 (IgG) were found in females when compared with those of corresponding males of all tested mouse strains ((A), * p < 0.05, Mann–Whitney rank sum test). Significantly lower levels of E4 IgG were found in B6 females when compared to that of CCR2ko and Stat1ko females ((A), # p < 0.05, Mann–Whitney rank sum test). Significantly higher levels of antibodies were found in females of CCR2ko for IgG3 (E) but not IgG1 (B), IgG2b (C), and IgG2c (D) isotypes. Significantly lower levels of E4 IgG3 were found in B6 females when compared to that of CCR2ko and Stat1ko females ((E), # p < 0.05, Mann–Whitney rank sum test, * for B6 vs. stat1ko females).