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. 2023 Dec 14;28(24):8095. doi: 10.3390/molecules28248095

Table 3.

IC50 values of (E)-9-(2-nitrovinyl)anthracene compounds 19a, 19g, 19i, 19l and 19m in HG-3 and PGA-1 CLL cell lines.

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Compound
Number		 HG-3
IC50 (µM) a 		PGA-1
IC50 (µM) a 		logP b
19a 2.43 3.10 4.57
19g 0.17 1.29 4.49
19i 3.85 4.40 5.07
19l 5.40 1.30 5.59
19m 0.70 9.10 5.99
Fludarabine 28.1 32.0 −2.5 b

a IC50 values are half-maximal inhibitory concentrations required to block the growth stimulation of HG3 and PGA-1 cells. Values represent the mean ± SEM (error values × 10−6) for at least three experiments performed in triplicate at 24 h. Treatment at eight different concentrations (0.001–50 μM) was used for the determination of the IC50 values for each compound. b Predicted property using Chemaxon.