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. 1985 Dec;79(4):968–972. doi: 10.1104/pp.79.4.968

Interaction of Wheat Germ Ca2+-Dependent Protein Kinases with Calmodulin Antagonists and Polyamines 1

Gideon M Polya 1, Vito Micucci 1
PMCID: PMC1075008  PMID: 16664554

Abstract

The two soluble Ca2+-dependent protein kinases resolved from wheat (Triticum aestivum) embryo (protein kinases I and II) are inhibited by the phenothiazine-derived calmodulin antagonists trifluoperazine fluphenazine, and chlorpromazine. Protein kinases I and II are also inhibited by a variety of other calmodulin antagonists (including calmidazolium, amitriptyline, and iprindole), phosphodiesterase inhibitors (including flufenamic acid and papavarine) and by lanthanides. A number of compounds that inhibit mammalian Ca2+ - and phospholipid-activated protein kinase (protein kinase C) including quercetin, polymixin B sulfate, and polyamines (as well as phenothiazine derivatives) also inhibit protein kinases I and II. Poly-l-lysine and poly-l-ornithine activate both plant Ca2+-dependent protein kinases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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