Abstract
Cyanobacterin is a secondary metabolite produced by the cyanobacterium (blue-green alga) Scytonema hofmanni. The compound had previously been isolated and chemically characterized. It was shown to inhibit the growth of algae at a concentration of approximately 5 micromolar. Cyanobacterin also inhibited the growth of angiosperms, including the aquatic, Lemna, and terrestrial species such as corn and peas. In isolated pea chloroplasts, cyanobacterin inhibited the Hill reaction when p-benzoquinone, K3Fe(CN)6, dichlorophenolindophenol, or silicomolybdate were used as electron acceptors. The concentration needed to inhibit the Hill reaction in photosystem II was generally lower than the concentration of the known photosystem II inhibitor 3-(3,4-dichlorophenyl)-1,1-dimethyl urea. Cyanobacterin had no effect on electron transport in photosystem I. The data indicate that cyanobacterin inhibits O2 evolving photosynthetic electron transport in all plants and that the most probable site of action is in photosystem II.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Berg S. P., Izawa S. Pathways of silicomolybdate photoreduction and associated photophosphorylation in tobacco chloroplasts. Biochim Biophys Acta. 1977 May 11;460(2):206–219. doi: 10.1016/0005-2728(77)90207-9. [DOI] [PubMed] [Google Scholar]
- Giaquinta R. T., Ort D. R., Dilley R. A. The possible relationship between a membrane conformational change and photosystem II dependent hydrogen ion accumulation and adenosine 5'-triphosphate synthesis. Biochemistry. 1975 Oct 7;14(20):4392–4396. doi: 10.1021/bi00691a008. [DOI] [PubMed] [Google Scholar]
- Mason C. P., Edwards K. R., Carlson R. E., Pignatello J., Gleason F. K., Wood J. M. Isolation of chlorine-containing antibiotic from the freshwater cyanobacterium Scytonema hofmanni. Science. 1982 Jan 22;215(4531):400–402. doi: 10.1126/science.6800032. [DOI] [PubMed] [Google Scholar]
- Trebst A. Measurement of Hill reactions and photoreduction. Methods Enzymol. 1972;24:146–165. doi: 10.1016/0076-6879(72)24065-4. [DOI] [PubMed] [Google Scholar]