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Overview of the analysis. The four substance use traits (SUTs) that were used in multi-trait analysis of genome-wide association studies (MTAG) analysis have pairwise genetic correlations between 0.45 and 0.80. For each SUT MTAG-genome-wide association studies (GWAS) result, we identified novel loci, performed gene-set analysis, protein–protein interaction analysis and examined the increased predictive power of the corresponding polygenic risk score.
