Fig. 4.

Differential co-expression of the gut microbiome, circulating metabolome and protein markers of immune and inflammatory response induced by the 8-week intervention. Differentially correlated module pairs between baseline usual diet (left column) and 8-weeks post intervention (middle column). Heatmaps depict Fisher's z-transformation of Pearson correlation coefficients between paired features that significantly increased or decreased pre-and post-intervention (FDR adjusted p-value <0.25).