Table 5.

Therapeutic potential of the herbal formulation of C. spinosa combined with honey used for improving the toxic effects of trichloroacetic acid.

Model	Method	Intervention (Activity)	Outcome	Reference
Swiss albino male mice intoxicated with trichloroacetic acid (TCA).	120 male albino mice were selected. Group I: It was treated with distilled water (4 ml/kg for 3 and 6 weeks) and kept as control. Group II: It was treated orally with honey at a dose of 4 ml/kg for 3 consecutive weeks. Group III: It wasgivencombination of Capparis spinosa leaf powder fortified with honey (40 mg/kg body weight) for 3 weeks. Group IV: It was treated with extract of Capparis spinosa leaf powder alone orally for 3 weeks. Group V:It was given TCA alongwith drinking water (500 mg/kg), and then left to recover for 3 weeks. Group VI: It was given TCA for 6 weeks and then given a formulation of honey &Capparis spinosa for 3 weeks.	The group treated alone with TCA for 6 weeks caused 6 % mortality in the mice. The death rate rose to 14 % in the mice left for recovery.The least mortality was reported in the mice given TCA followed bythecombination of Capparis spinosa and honey. This group also exhibiteda significant increase in the final body weight.	The results indicate that a mixture of leaf powder of Capparis spinosa and honey at a prescribed dose (40 mg/kg body weight) for 3 weeks improved the toxicity caused by trichloroacetic acid and improved both histopathological lesions, biochemical attributes and decreased percentage of mortality as well.	[34]