Figure 3.
OrgOCs platform for vascularization in biological study. (A) The formation of vascularized placental-like organoids resembled first-trimester human placental development in a microfluidic chip platform. Adapted with permission 30. Copyright 2022 Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers. (B) Interstitial flows could expand the endogenous pool of endothelial progenitor cells and enhance the vascularization and maturation of kidney organoids derived from hiPSCs. Adapted with permission 212. Copyright 2021 MDPI. (C) Implanting the functional neurovascular cerebral organoids on a chip induced angiogenesis by co-culturing adscititious endothelial cells. Adapted with permission 61. Copyright 2022 The Royal Society of Chemistry. (D) Organoids with a perfused microvasculature reconstituted the process of monocyte infiltration into colon organoids in the circulatory system using customizable IFlowPlates. Adapted with permission 137. Copyright 2020 Wiley-VCH GmbH.