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. 2023 Dec 2;15(12):e49834. doi: 10.7759/cureus.49834

Prevalence of Highly Sensitive Personality and Its Relationship With Depression, and Anxiety in the Saudi General Population

Mohammed Dosari 1, Saud K AlDayel 2, Khalid M Alduraibi 2, Abdulaziz A AlTurki 2,, Fahad Aljehaiman 2, Sultan Alamri 2, Hamad S Alshammari 2, mosad Alsuwailem 2
Editors: Alexander Muacevic, John R Adler
PMCID: PMC10758235  PMID: 38164317

Abstract

Background

Highly sensitive personality (HSP) occurs in those who experience stronger processing of emotions and responses to both internal and external stimuli; this, in turn, could cause persons with highly sensitive personalities to suffer from affective disorders such as depression and anxiety at higher rates. This study aimed to measure the prevalence of highly sensitive personality and its relationship with depression and anxiety among the Saudi general population.

Subject and methods

This cross-sectional study was conducted among the general population in Saudi Arabia. A self-administered questionnaire was sent to the target population using an online survey. The questionnaire includes sociodemographic data (i.e., age, gender, marital status, etc.), the Highly Sensitive Person Scale to measure the degree of sensitivity, and the Hospital Anxiety and Depression Scale (HADS) to measure anxiety and depression.

Results

Of the 438 participants, 72.6% were females, and 48.9% were aged between 18 to 25 years. The prevalence of HSP in this study was 29%. Abnormal levels of anxiety and depression were found in 29.5% and 19.9%, respectively. Significant relationships were observed between HSP in terms of anxiety (p<0.001) and depression (p=0.001). It is interesting to note that a previous diagnosis of mental disorder was identified as a significant risk factor for HSP, anxiety, and depression.

Conclusion

There was a high prevalence of HSP in our population, which was significantly associated with anxiety and depression. Further, female participants were more likely to exhibit HSP and anxiety but not depression. These findings highlight the importance of prevention programs intended for highly sensitive persons with associated mental conditions.

Keywords: sensory processing sensitivity, general population, depression, anxiety, highly sensitive personality

Introduction

Highly sensitive personality (HSP) or sensory processing sensitivity (SPS) is a hereditary personality trait that is associated with a genetic component leading to deep processing and response to external stimuli [1,2]. The external stimuli can involve varied aspects such as noises, caffeine, pain, and hunger sensations. Also, it can affect other parts of the person's life such as their personal relationship, work colleagues, and school peers [2-4]. People with HSP have a higher awareness of their surroundings and the moods of others which can lead to more empathetic responses due to their deep processing [5,6]. However, this trait of deep thinking and increased empathy can lead to absorbing other people's emotions and this can become overwhelming for them [7]. In addition, people with HSP have higher rates of neuroticism and introversion compared to the general population, which can put them at a higher risk for some affective disorders [8]. According to Aron (2010), it has been conducted that around half of patients who complain of shyness as well as anxiety and depressive symptoms have HSP [9]. 

In recent years many researchers have made a correlation between highly sensitive personality and mood disorders such as depression and anxiety. A study performed on university students in 2018 showed there’s a direct relation between overstimulation in highly sensitive persons and depressive tendencies [10]. It is important to mention the factors that come into play when discussing affective disorders and HSP. For instance, environmental factors play a key role; depression and anxiety have been linked with high sensory processing sensitivity (SPS) which was primarily found in individuals subjected to negative childhood experiences [11]. Further supporting this claim is a study using a shortened version of the Highly Sensitive Person Scale (HSPS) which categorized patients’ responses into three factors: ease of excitation (EOE), low sensory threshold (LST), and aesthetic sensitivity (AE). This study proved that there’s a positive correlation between EOE and LST with the degree of psychological health complaints [12]. How external and internal stimuli are perceived has also been shown to increase the risk of developing anxiety in adults, according to a study conducted in Australia using HSPS [13].

This study aims to determine the prevalence and relationship between highly sensitive personality, depression, and anxiety among the general population of Saudi Arabia and recognize the factors that lead to their development. Moreover, this study will be helpful in increasing the level of awareness and knowledge among the general population about these personality traits and how they influence other factors in persons’ lives. This study will also be beneficial for healthcare practitioners in identifying HSP and associated disorders and implementing the best management options for these patients. 

Materials and methods

This cross-sectional study was conducted with participants from the general population of Saudi Arabia. The co-investigators collected the data using a self-administered questionnaire. The population included in this study were both female and male, aged 18 years and above, ranging from different socioeconomic backgrounds, education levels, and occupations. However, nationality was not specified in the questionnaire. A non-probability convenience sampling technique was used by including all those who met our criteria. The total number of participants in the study was 438.

Participation in the study was voluntary; collection of data ceased when the sample size of 438 was fulfilled. Collection of the data was through an online questionnaire and consent to use the data was taken before participating in the study. Approval of the study was granted by King Abdullah International Medical Research Center (KAIMRC) and Institutional Review Board approval (IRB) was issued thereafter (study number: NRC23R/362/06; IRB Approval No.: IRB/1564/23; E-CTS Ref No.: RYD-23-419812-96052; approval date: June 27, 2023).

HSP was measured by using the Highly Sensitive Person Questionnaire (HSP Scale) developed by Aron and Aron [14]. This is a 27-item questionnaire measuring the sensitive personality of an individual; those scoring 14 and above were considered highly sensitive. Likewise, the anxiety and depression of the general population were measured with the Hospital Anxiety and Depression Scale (HADS) developed by Zigmond and Snaith [15]. This is a validated questionnaire measuring the level of anxiety and depression of the subject consisting of 14 items (seven items each), a four-point Likert scale with categories ranging from 0 to 3 points. Scores of 7 and 10 points use cutoff points between normal, borderline, and abnormal.

Categorical variables were shown as numbers and percentages. Continuous variables were calculated and given as mean and standard deviation. The relationship between the levels of HSP, anxiety, and depression in terms of socio-demographic data collected was determined using the chi-square test. Based on the significant results, multivariate regression models were performed to determine the independent significant predictors associated with high levels of HSP, as well as abnormal levels of anxiety and depression. Statistical significance was set to p<0.05. All data analyses were carried out using the IBM SPSS v. 26 (IBM Corp., Armonk, NY).

Results

This cross-sectional survey recruited 438 participants. As described in Table 1, the most common age group was 18 to 25 years (48.9%), with females being dominant (72.6%). Participants who lived in the Central Region constituted 38.8%. Most of the respondents were bachelor's degree holders (67.1%). Respondents who were currently employed constituted 25.3%. Among those working (n=266), 75.6% were government employees, mostly in a non-healthcare institution (64.7%). Of the healthcare employees (n=94), 22.3% were doctors. With respect to monthly income, 57.1% were earning less than 10,000 SAR per month. With respect to marital status, 53.9% had never been married.

Table 1. Socio-demographic characteristics of participants (n=438).

Study variables N (%)
Age group in years  
  18-25 years 214 (48.9%)
  26-35 years 67 (15.3%)
  36-50 years 76 (17.4%)
  >50 years 81 (18.5%)
Gender  
  Male 120 (27.4%)
  Female 318 (72.6%)
Residence region  
  Central Region 170 (38.8%)
  Eastern Region 119 (27.2%)
  Northern Region 45 (10.3%)
  Southern Region 12 (02.7%)
  Western Region 92 (21.0%)
Educational level  
  Intermediate school 2 (0.50%)
  Secondary school 103 (23.5%)
  Bachelor's degree 294 (67.1%)
  Master's degree 31 (07.1%)
  PhD degree 8 (01.8%)
Employment status  
  Employed 111 (25.3%)
  Unemployed 81 (18.5%)
  Retired 75 (17.1%)
  Student 171 (39.0%)
Job type (n=266)  
  Government employee 201 (75.6%)
  Non-government employee 65 (24.4%)
Institution (n=266)  
  Healthcare 94 (35.3%)
  Non-healthcare 172 (64.7%)
If you are a health employee, choose your job (n=94)  
  Unspecified 55 (58.5%)
  Doctor 21 (22.3%)
  Nurse 09 (09.6%)
  Specialist 05 (05.3%)
  Pharmacist 02 (02.1%)
  Dentist 02 (02.1%)
Monthly income (SAR)  
  <10,000 250 (57.1%)
  10,001 – 20,000 116 (26.5%)
  20,001 – 30,000 40 (09.1%)
  >30,000 32 (07.3%)
Marital status  
  Single 236 (53.9%)
  Married 180 (41.1%)
  Divorced 19 (04.3%)
  Widowed 03 (0.70%)

In Figure 1, the most commonly diagnosed mental disorders were depression (6.6%) and anxiety (4.3%).

Figure 1. Previous history of mental disorder.

Figure 1

The prevalence of highly sensitive personality, depression, and anxiety has been elaborated in Table 2. It can be observed that the total mean score for HSP was 23.7 (SD 3.86), with 29% considered as highly sensitive and the rest were normal (71%). Regarding anxiety, the total mean score was 7.89 (SD 4.65), with 29.5% classified as abnormal levels. Regarding depression, the total mean score was 7.09 (SD 4.00), with 19.9% considered abnormal levels (see also Figure 2).

Table 2. Prevalence of highly sensitive personality, depression, and anxiety among the general population (n=438).

Variables N (%)
HSP total score (mean ± SD) 23.7 ± 3.86
HSP level  
  Highly sensitive 127 (29.0%)
  Normal 311 (71.0%)
Anxiety score (mean ± SD) 7.89 ± 4.65
  Anxiety level  
  Normal 221 (50.5%)
  Borderline 88 (20.1%)
  Abnormal 129 (29.5%)
Depression score (mean ± SD) 7.09 ± 4.00
  Depression level  
  Normal 242 (55.3%)
  Borderline 109 (24.9%)
  Abnormal 87 (19.9%)

Figure 2. Level of anxiety and depression .

Figure 2

When measuring the relationship between HSP in terms of anxiety and depression levels (Table 3), it was found that a highly sensitive personality was significantly more common among those with abnormal levels of anxiety (p<0.001) and depression (p=0.001).

Table 3. Relationship between highly sensitive personality according to anxiety and depression (n=438).

  § P-value has been calculated using a chi-square test.

    ** Significant at p<0.05 level.

Factor Level of HSP P-value §
Highly N (%) (n=127) Normal N (%) (n=311)
Anxiety      
  Normal 35 (27.6%) 186 (59.8%) <0.001 **
  Borderline 23 (18.1%) 65 (20.9%)
  Abnormal 69 (54.3%) 60 (19.3%)
Depression      
  Normal 59 (46.5%) 183 (58.8%) 0.001 **
  Borderline 29 (22.8%) 80 (25.7%)
  Abnormal 39 (30.7%) 48 (15.4%)

We used the chi-square test in Table 4 to determine the relationship between the HSP level and the participants' socio-demographic characteristics. It was revealed that the prevalence of highly sensitive personality was significantly more common among the younger age group (p=0.003), female gender (p<0.001), lower monthly income (p<0.001), never been married (p=0.001), and those with a previous diagnosis of mental disorder (p<0.001).

Table 4. Relationship between the level of HSP and sociodemographic characteristics of participants .

§ P-value has been calculated using chi-square test.

  ** Significant at p<0.05 level.

Factor Level of HSP P-value §
Highly N (%) (n=127) Normal N (%) (n=311)
Age group in years      
≤30 years 86 (67.7%) 163 (52.4%) 0.003 **
>30 years 41 (32.3%) 148 (47.6%)
Gender      
Male 18 (14.2%) 102 (32.8%) <0.001 **
Female 109 (85.8%) 209 (67.2%)
Educational level      
Secondary or below 29 (22.8%) 76 (24.4%) 0.721
Bachelor or higher 98 (77.2%) 235 (75.6%)
Employment status      
Employed 30 (23.6%) 81 (26.0%) 0.067
Unemployed/Retired 37 (29.1%) 119 (38.3%)
Student 60 (47.2%) 111 (35.7%)
Monthly income (SAR)      
<10,000 90 (70.9%) 160 (51.4%) <0.001 **
≥10,000 37 (29.1%) 151 (48.6%)
Marital status      
Never been married 84 (66.1%) 152 (48.9%) 0.001 **
Been married 43 (33.9%) 159 (51.1%)
Previous diagnosis of mental disorder      
Yes 33 (26.0%) 25 (08.0%) <0.001 **
No 94 (74.0%) 286 (92.0%)

We also used the chi-square test to determine the relationship between the anxiety level and participants' socio-demographics (Table 5). It was found that the prevalence of abnormal anxiety levels was significantly more common among women (p=0.002), students (p=0.002), unmarried persons (p<0.001) and those under 30 years of age (p<0.001), earning under 10,000 SAR a month (p=0.001), and with a previous diagnosis of mental disorder (p=0.001).

Table 5. Relationship between the level of anxiety and sociodemographic characteristics of participants (n=438).

§ P-value has been calculated using the chi-square test.

  ** Significant at p<0.05 level.

Factor Level of anxiety P-value §
Normal N (%) (n=221) Borderline N (%) (n=88) Abnormal N (%) (n=129)
Age group in years        
  ≤30 years 100 (45.2%) 60 (68.2%) 89 (69.0%) <0.001 **
  >30 years 121 (54.8%) 28 (31.8%) 40 (31.0%)
Gender        
  Male 77 (34.8%) 15 (17.0%) 28 (21.7%) 0.002 **
  Female 144 (65.2%) 73 (83.0%) 101 (78.3%)
Educational level        
  Secondary or below 48 (21.7%) 21 (23.9%) 36 (27.9%) 0.425
  Bachelor or higher 173 (78.3%) 67 (76.1%) 93 (72.1%)
Employment status        
  Employed 62 (28.1%) 18 (20.5%) 31 (24.0%) 0.002 **
  Unemployed/Retired 93 (42.1%) 27 (30.7%) 36 (27.9%)
  Student 66 (29.9%) 43 (48.9%) 62 (48.1%)
Monthly income (SAR)        
  <10,000 106 (48.0%) 59 (67.0%) 85 (65.9%) 0.001 **
  ≥10,000 115 (52.0%) 29 (33.0%) 44 (34.1%)
Marital status        
  Never been married 91 (41.2%) 55 (62.5%) 90 (69.8%) <0.001 **
  Been married 130 (58.8%) 33 (37.5%) 39 (30.2%)
Previous diagnosis of mental disorder        
  Yes 21 (09.5%) 08 (09.1%) 29 (22.5%) 0.001 **
  No 200 (90.5%) 80 (90.9%) 100 (77.5%)

We also used the chi-square test in Table 6 to find the relationship between the level of depression and the sociodemographic characteristics of participants. It was revealed that the prevalence of abnormal depression levels was significantly more common among the younger age group (p<0.001), students (p<0.001), those who had never been married (p<0.001), and previous diagnoses of mental disorder (p<0.001).

Table 6. Relationship between the level of depression and sociodemographic characteristics of participants (n=438).

  § P-value has been calculated using the chi-square test.

  ** Significant at p<0.05 level.

Factor Level of depression P-value §
Normal N (%) (n=242) Borderline N (%) (n=109) Abnormal N (%) (n=87)
Age group in years        
  ≤30 years 114 (47.1%) 73 (67.0%) 62 (71.3%) <0.001 **
  >30 years 128 (52.9%) 36 (33.0%) 25 (28.7%)
Gender        
  Male 75 (31.0%) 23 (21.1%) 22 (25.3%) 0.140
  Female 167 (69.0%) 86 (78.9%) 65 (74.7%)
Educational level        
  Secondary or below 57 (23.6%) 30 (27.5%) 18 (20.7%) 0.524
  Bachelor or higher 185 (76.4%) 79 (72.5%) 69 (79.3%)
Employment status        
  Employed 63 (26.0%) 28 (25.7%) 20 (23.0%) <0.001 **
  Unemployed/Retired 108 (44.6%) 26 (23.9%) 22 (25.3%)
  Student 71 (29.3%) 55 (50.5%) 45 (51.7%)
Monthly income (SAR)        
  <10,000 131 (54.1%) 66 (60.6%) 53 (60.9%) 0.383
  ≥10,000 111 (45.9%) 43 (39.4%) 34 (39.1%)
Marital status        
  Never been married 99 (40.9%) 74 (67.9%) 63 (72.4%) <0.001 **
  Been married 143 (59.1%) 35 (32.1%) 24 (27.6%)
Previous diagnosis of mental disorder        
  Yes 17 (07.0%) 23 (21.1%) 18 (20.7%) <0.001 **
  No 225 (93.0%) 86 (78.9%) 69 (79.3%)

We also conducted multivariate regression analyses to identify the independent risk factors for high levels of HSP and abnormal levels of anxiety and depression (Table 7). In the HSP model, it was revealed that female gender and previous diagnosis of mental disorders were identified as the significant risk factors for highly sensitive personality, while higher monthly income was identified as the preventive factor. This further suggests that compared to males, females were 2.69 times more likely to exhibit HSP (AOR=2.686; 95% CI=1.514-4.762; p=0.001). Participants who were diagnosed with mental disorders were 3.85 times more likely to be associated with HSP than those who did not have the diagnosis (AOR=3.855; 95% CI=2.117-7.022; p<0.001). On the contrary, respondents who were high-earners had a decreased risk of being HSP by at least 44% as compared to respondents who were earning less (AOR=0.564; 95% CI=0.346-0.920; p=0.022). In the anxiety model, it was observed that a previous diagnosis of mental disorder was identified as the independent significant risk factor for anxiety while having been married was identified as the significant protective factor. This further indicates that respondents who were previously diagnosed with mental disorders were predicted to increase the risk for anxiety by at least 2.74 times higher (AOR=2.743; 95% CI=1.526-4.933; p=0.001), while respondents who had been married were predicted to decrease the risk of anxiety by at least 62% (AOR=0.383; 95% CI=0.179-0.822; p=0.014). Finally, in the depression model, a previous diagnosis of a mental disorder was also identified as the significant risk factor for depression, whereas having been married was identified as the significant protective factor. This further indicates that respondents who were diagnosed with mental disorders were 1.99 times more likely to be associated with the risk of depression (AOR=1.999; 95% CI=1.063-3.759; p=0.032), while respondents who had been married were predicted to decrease the risk of depression by at least 62% as compared to those who had never been married (AOR=0.379; 95% CI=0.157-0.914; p=0.031).

Table 7. Multivariate regression analysis to determine the significant independent predictors of HSP as well as abnormal levels of anxiety and depression (n=438).

AOR: adjusted odds ratio; CI: confidence interval; SAR: Saudi Arabian Riyal; Ref: reference 

** Significant at p<0.05 level.

Parameters AOR 95% CI P-value
HSP Model      
Age group in years ≤30 years Ref    
>30 years 0.932 0.438 – 1.983 0.855
Gender Male Ref    
Female 2.686 1.514 – 4.762 0.001 **
Monthly income (SAR) <10,000 Ref    
≥10,000 0.564 0.346 – 0.920 0.022 **
Marital status Never been married Ref    
Been married 0.641 0.309 – 1.331 0.233
Previous diagnosis of mental disorder Yes 3.855 2.117 – 7.022 <0.001 **
No Ref    
Anxiety Model      
Age group in years ≤30 years Ref    
>30 years 1.012 0.447 – 2.293 0.977
Gender Male Ref    
Female 1.355 0.818 – 2.247 0.238
Employment status Employed Ref    
Unemployed/retired 0.73 0.375 – 1.424 0.356
Student 0.959 0.505 – 1.820 0.898
Monthly income (SAR) <10,000 Ref    
≥10,000 0.801 0.491 – 1.305 0.372
Marital status Never been married Ref    
Been married 0.383 0.179 – 0.822 0.014 **
Previous diagnosis of mental disorder Yes 2.743 1.526 – 4.933 0.001 **
No Ref    
Depression Model      
Age group in years ≤30 years Ref    
>30 years 1.031 0.404 – 2.628 0.95
Employment status Employed Ref    
Unemployed/retired 0.939 0.450 – 1.961 0.868
Student 1.17 0.568 – 2.408 0.67
Marital status Never been married Ref    
Been married 0.379 0.157 – 0.914 0.031 **
Previous diagnosis of mental disorder Yes 1.999 1.063 – 3.759 0.032 **
No Ref    

Discussion

This study is carried out to examine the prevalence and relationship between HSP, depression, and anxiety among the Saudi general population. The prevalence of HSP in this study was 29%, which was higher than the estimated prevalence of 15% to 20% [3]. Furthermore, the rate of HSP was higher among the younger age group, female gender, lower economic status, single participants, and previous diagnosis of mental disorders. However, in our adjusted regression model, female gender and previous diagnosis of mental disorders were identified as the significant risk factors for HSP, whereas higher monthly income was identified as an HSP preventive factor. This is almost consistent with the study of Pérez-Chacón et al. [16] Based on their reports, women were more associated with higher SPS scores and poorer health-related quality of life than men. Also, they observed that conscientiousness, extraversion, and adaptive coping strategies were determined as protective factors, while maladaptive coping techniques and neuroticism were also identified as risk factors. However, Listou Grimen and Diseth [12] documented that SPS was positively associated with neuroticism and openness but inversely associated with extraversion. Additionally, subjective health complaints (SHC) are greatly influenced by the personality traits of neuroticism more than SPS factors.

Studies suggest an association between HSP and psychological disorders. For instance, Yano and Oishi, [10] reported that low sensory threshold (LST) and ease of excitation (EOE) were associated with depressive symptoms, while aesthetic sensitivity (AES) was inversely associated with depressive tendencies. Similarly, Liss et al. [17] EOE and LST were linked to autism symptoms, anxiety, depression, and alexithymia. AES was linked to the symptoms of autism and anxiety but not to depression. On the other hand, Grinapol et al. [18] found a positive correlation between SPS and post-traumatic stress symptoms (PTSS) at follow-up. However, SPS was not seen to influence PTSS at follow-up when controlled for early PTSS. Likewise, Pluess and Boniwell [19] revealed that SPS was a significant factor in treatment response, wherein the prevention program effectively reduced depression among girls with HSP but was ineffective among girls scoring low on the same measure. In our study, however, HSP was significantly related to anxiety and depression, with more than half of HSP respondents (54.3%) detected to have abnormal anxiety levels (p<0.001), while less than one-third (30.7%) had abnormal depression (p=0.001).

Conversely, a mediation analysis documented by Brindle et al. [7] showed that SPS and depression were mediated by the lack of individual access to emotional regulation strategies, higher emotional awareness, and insufficient acceptance of feeling distressed. In addition, SPS and anxiety and stress symptoms were also mediated partially by the blends of these variables. Another study conducted by Benham [20] disclosed that the inclusion of an interaction term in the model proved to be non-significant, indicating that an additive model best explains the associations between SPS, stress, and health. However, in our study, having been married was associated with improved mental conditions, particularly with anxiety and depression, but not with HSP.

It is important to note that anxiety and depression were also common in our population. The rate of abnormal levels was 29.5% and 19.9% for anxiety and depression, respectively. Influencing factors of anxiety and depression include age group, employment status, marital status, and previous history of mental disorder. However, in our regression estimates, only a previous history of mental disorder was determined as the significant risk factor for both mental conditions. In Spain [21], healthcare workers were seen to have an increased personal realization and depersonalization, while educators demonstrated higher compassion fatigue. In addition, they cited that certain characteristics of SPS had driven the occurrence of burnout and compassion fatigue. Another survey done among Japanese university students [10] reported that the association between depressive symptoms and LST or EOE was mediated by regular physical exercise. The authors suggested that this effect was not conclusive and that longitudinal studies are needed to determine its cause and effect.

Limitations

This study has a few limitations. First, the self-reporting nature of the study may introduce the possibility of response bias. Second, the study was directed towards the Saudi population, generalizing the findings of this study might not be applicable due to cultural and social differences. Third, the study’s cross-sectional design limits its ability to establish casual relationships. On the contrary, this questionnaire was the first in the region to assess the prevalence of HSP and its relationship with depression and anxiety.

Conclusions

Highly sensitive personality was prevalent among our population. HSP significantly influences psychological conditions, including anxiety and depression. Further, female participants tended to have a highly sensitive personality regardless of mental conditions, while participants who had been married demonstrated improved mental conditions but not HSP. However, a previous diagnosis of mental disorder was the most significant risk factor in all three models used throughout. This study provides evidence of an association between HSP and abnormal mental conditions. However, given the scarcity of this study discipline in our region, more prospective studies are required to establish their associations.

The authors have declared that no competing interests exist.

Author Contributions

Concept and design:  Abdulaziz A. AlTurki, Mohammed Dosari, Khalid M. Alduraibi, Fahad Aljehaiman, Saud K. AlDayel , Sultan Alamri, Hamad S. Alshammari, mosad Alsuwailem

Acquisition, analysis, or interpretation of data:  Abdulaziz A. AlTurki, Mohammed Dosari, Khalid M. Alduraibi, Fahad Aljehaiman, Saud K. AlDayel , Sultan Alamri, Hamad S. Alshammari, mosad Alsuwailem

Drafting of the manuscript:  Abdulaziz A. AlTurki, Mohammed Dosari, Khalid M. Alduraibi, Fahad Aljehaiman, Saud K. AlDayel , Sultan Alamri, Hamad S. Alshammari, mosad Alsuwailem

Critical review of the manuscript for important intellectual content:  Abdulaziz A. AlTurki, Mohammed Dosari, Khalid M. Alduraibi, Fahad Aljehaiman, Saud K. AlDayel , Sultan Alamri, Hamad S. Alshammari, mosad Alsuwailem

Supervision:  Abdulaziz A. AlTurki, Mohammed Dosari, Khalid M. Alduraibi, Fahad Aljehaiman, Saud K. AlDayel , Sultan Alamri, Hamad S. Alshammari, mosad Alsuwailem

Human Ethics

Consent was obtained or waived by all participants in this study. King Abdullah International Medical Research Center (KAIMRC) issued approval IRB/1564/23

Animal Ethics

Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue.

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