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. 1992 Dec;100(4):1982–1986. doi: 10.1104/pp.100.4.1982

A Cyanobacterial Gene Encoding Peptidyl-Prolyl cis-trans Isomerase 1

Miriam Hassidim 1, Rakefet Schwarz 1, Judy Lieman-Hurwitz 1, Eduardo Marco 1, Michal Ronen-Tarazi 1, Aaron Kaplan 1
PMCID: PMC1075894  PMID: 16653227

Abstract

The rotA gene encoding peptidyl-prolyl cis-trans isomerase has been identified, sequenced, and shown to be transcribed in the cyanobacterium Synechococcus sp. PCC7942. Inactivation of the gene by replacement of a region containing the open reading frame with a gene conferring kanamycin resistance resulted in merodiploids containing both the wild type and the modified genomic region. We were not able to isolate a kanamycin-resistant mutant in which all the genomic wild-type copies were substituted, which suggests that such replacement could have been lethal.

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Selected References

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